盆痛宁方治疗盆腔炎性疾病后遗症（湿热瘀结证）的临床研究

【作者】 郑超；

【导师】 陈艳；

【作者基本信息】 北京中医药大学 ， 中医妇科学， 2012， 硕士

【摘要】 本论文分为两部分,第一部分,对近五年来关于盆腔炎性疾病后遗症诊断治疗的研究进展做了文献综述。盆腔炎性疾病后遗症是育龄期妇女的常见病、多发病,具有发病率高、病情缠绵难愈、后遗症严重、复发率高等特点,严重影响广大育龄期妇女的身心健康,探讨该病的发病机制及治疗方案已成为妇科临床的热门课题之一。盆腔炎性疾病后遗症是现代医学名词,历代中医古籍当中无此病名,可散见于“瘾瘕”“带下病”“妇人腹痛”“热入血室”“不孕”等相关章节中。现代医学至今尚未阐明其发病机制,中医普遍认为本病多因经行产后,胞门未闭,风寒湿热之邪,或虫毒乘虚内侵,与冲任气血相搏结,瘀积于胞宫；久则耗伤气血,导致正气虚损,尤以气虚、肾虚为主。病性属本虚标实、虚实错杂。目前现代医学对此病治疗效果不理想,中医药治疗本病具有独特优势,治疗方法和给药途径多样化,包括内治法、外治法,以辨证论治为核心,结合多种方法的综合疗法被认为是临床疗效最为肯定的方法。第二部分,对导师陈艳教授的盆痛宁方治疗盆腔炎性疾病后遗症(湿热瘀结证)进行了临床研究。目的：观察盆痛宁方治疗盆腔炎性疾病后遗症(湿热瘀结证)的临床疗效方法：将门诊收集的符合纳入标准的60例盆腔炎性疾病后遗症(湿热瘀结证)患者随机分成观察组及治疗组各30例,治疗组予盆痛宁方口服治疗,对照组予康妇炎胶囊口服治疗。疗程为8周。记录治疗前及治疗8周后的中医证候及局部体征,并进行积分。然后对治疗前后的数据资料进行统计学处理,以进行疗效对比。结果：综合疗效方面,盆痛宁方治疗组愈显率46.7%、总有效率为96.7%,康妇炎胶囊对照组愈显率16.7%、总有效率为90%；中医证候疗效方面,治疗组愈显率60%、总有效率为93.3%,对照组愈显率20%、总有效率为90%;局部体征疗效方面,治疗组愈显率20%、总有效率为86.7%,对照组愈显率10%、总有效率为73.3%。两组组间综合疗效、中医证候疗效的差异有统计学意义(P<0.05),局部体征疗效的差异无统计学意义(P>0.05)。两组组内治疗后的综合积分、中医证候积分及局部体征积分与治疗前相比均有明显降低,P<0.05有统计学意义；两组间进行比较,则治疗组在改善综合积分和中医证候积分方面优于对照组,数据差异有统计学意义(P<0.05)；局部体征积分组间差异无统计学意义(P>0.05)。说明盆痛宁方及康妇炎胶囊治疗盆腔炎性疾病后遗症(湿热瘀结证)均有明显的疗效,但盆痛宁方在综合疗效、中医证候疗效方面优于康妇炎胶囊,在改善局部体征方面二者疗效相似。更多还原

【Abstract】 This thesis is divided into two parts. The first part is an overview of sequelae of PID diagnosis and treatment research in the last five years.Sequelae of Pelvic Inflammatory disease in women of childbearing age is a common disease, with high incidence rate, long course, sequelae of severe refractory, high recurrence rate. Sequelae of PID causes serious impact on their physical and mental health. To explore the pathogenesis and the treatment method has become one of the hot topics in gynecology.Sequelae of PID is the modern medical terminology, ancient Chinese medicine books do not have such a name. The effect of modern medical treatment on this disease is not ideal, traditional Chinese medicine treatment of the disease has a unique advantage, the methods of treatment and the route of administration is diversification, Syndrome Differentiation and Treatment is the core, combined with a variety of methods of comprehensive therapy is considered the most effective method.The second part is a clinical study about the "Pentongning Fang"Objective:The aim of this research is to observe the clinical efficacy of "Pentongning Fang" for the treatment of sequelae of PID (syndrome of damp-heat and blood-stasis obstruction)Methods:60cases of sequelae of PID (syndrome of damp-heat and blood-stasis obstruct ion)who were collected from outpatient department, were randomly divided into two groups in the proportion of1to1. The30cases of treatment group were treated by "Pentongning Fang", and the other30cases were treated by Kangfuyan capsule for8weeks. All patients were evaluated at syndrome integrals, local physical sign integrals and integrated integrals before and after8weeks’ treatment. Then the data were statistically processed to compare the efficacy.Results:The total efficiency of the treatment group on integrated therapeutic effects was96.7%, on syndrome effects was93.3%, on local physical sign effects was86.7%; The total efficiency of the control group on integrated therapeutic effects was90%, on syndrome effects was90%, on local physical sign effects was73.3%; There was significant statistical differences in the therapeutic effects of both group (P<0.05).This research indicates that "Pentongning Fang" and Kangfuyan Capsule can remarkedlly improve the syndrome and physical sign on sequelae of PID. And the treatment group shows more positive effects than the control group on sequelae of PID.更多还原