【作者】 赵丽娜；

【导师】 顾大强；

【作者基本信息】 浙江大学 ， 机械设计及理论， 2012， 硕士

【摘要】 无针注射是利用药液的高速射流进入被注射体内,从而完成注射的技术过程。随着临床需要的推动和科学技术的发展,无针注射器技术呈现出蓬勃发展的态势,美国和欧洲已经有不同类型的商品面世,我国对无针注射的研究刚刚起步,目前还没有针对国内需求的产品上市。本文主要研究的内容如下：1.介绍了国内外已有的无针注射器技术,总结了现有无针注射器的技术指标及研究开发路线；2.进行无针注射器总体方案的设计,根据功能,将无针注射器分为机械结构部分、液压回路部分和电气控制部分,对各部分分析并确定最终采用的方案；3.根据分析及要求细化结构,对关键参数进行理论计算,设计得到产品三维模型,并且简化设计原理样机,验证无针注射器原理的可行性；4.基于前人设计的小孔喷射模型和液体撞击模型,对设计的机器进行仿真,得到对于各个高压空气弹簧的喷射特性分布；5.进行稳定性实验、高速摄像实验、注射仿生材料实验以及离体猪肉注射实验,四个实验层层递进,逐步证实了无针注射器原理样机的稳定性、模型仿真数据与实验数据的吻合度以及注射形态稳定性,并且验证了随着注射动力的增加,注射深度随之增加的结论。本文设计了机械机构、电气控制,对喷射过程进行理论分析,加工调试样机,并开展了多种实验,验证了样机的可行性和可靠性,完成了新产品开发的前期工作,为后续的新产品开发的完善奠定了坚实的基础。更多还原

【Abstract】 Needle-free injection makes use of high-speed liquid jet to inject liquid pharmaceutical into the body, thus completing the process of injection. Along with the clinical needs and the development of science and technology, needle-free injector technology presents a booming trend. United States and Europe have different types of products available. As the research of needle-free injection has just started, there is no product can meet the demand for the domestic market now.The main contents of this paper are as follows:Section 1 describes the existing needle-free injector technology home and abroad, and then summarizes the technical specifications along with the research and development route of the existing needle-free injector;The overall scheme design of the needle-free injector is introduced in section 2, which is divided into three parts---mechanical structure, hydraulic circuit and electrical control system according to the function. Followed by analyzing each part, the eventual adopted scheme is determined.Section 3 refines the structure according to the analysis and requirements, makes theoretical calculations of key parameters, gets the three-dimensional model for the product and then simply designs the prototype to test the possibility of the principle of needle-free injector.Based on the previous design of hole injection model and liquid hit model, Section 4 simulations the designed machine and then gets the distribution of injection characteristics for each high-pressure air spring.In section 5, four experiments of stability, high-speed camera, injection of biomimetic materials and pork injection is conducted, which gradually confirmed the stability of the prototype and Injection form, the goodness of fit of model simulation data and experimental data. In addition, the conclusion that injection depth will increase along with the increase of injection power is verified.This paper not only designs mechanical structure and electrical control, analysis the jet process theoretical, but also conducts a series of experiments after designing the prototype. Thanks to the above work, the feasibility and reliability of the prototype is verified and preliminary work to develop the new product is completed, laying a solid foundation for the followed-up improvement of the new product.更多还原