【作者】 侯峰；

【导师】 刘美凤； 莫启武；

【作者基本信息】 华南理工大学 ， 化学工程， 2011， 硕士

【摘要】 番石榴( Psidium guajava Linn1)为桃金娘科(Myrtaces)植物,最早在美洲热带地区发现,世界热带与亚热带地区均有分布,生于旷野或村庄附近。我国广西、广东、福建、四川和江西等省、自治区有栽培,台湾地区盛产。在番石榴种植和生长过程中会产生副产物——幼果和叶,大量的幼果和叶是被种植户丢弃。这两种副产物都可入药,广东中药材标准记载它们的主要功效是涩肠止泻,收敛止血,用于泄泻,下痢不止。国内外民间很早就用番石榴来降低血糖,近十几年来,经过研究人员大量的实验证明番石榴中的黄酮和多糖均有降血糖功效。将番石榴幼果和叶开发成降糖健康产品,可实现“变废为宝”。本课题以番石榴种植和生长过程中产生的副产物——番石榴幼果和叶为研究对象,以其降糖功效为切入点,研究其降糖成分——番石榴总黄酮和番石榴多糖的提取工艺,并开发出以番石榴幼果和叶为原料的降糖产品。本课题研究内容包括:①研究了番石榴叶和幼果中总黄酮和多糖的检测方法;②对广州地区不同地域不同品种的番石榴叶和幼果中总黄酮和多糖含量进行了比较研究;③对番石榴幼果中降糖成分提取工艺初步研究;④对番石榴叶中总黄酮提取纯化的小试、中试工艺进行了大量的优化实验研究;⑤对番石榴幼果水提物和叶总黄酮干膏提取物的降糖效果进行了动物实验验证。本研究的创新点在于:①首次对广州地区不同品种不同产地的番石榴叶和幼果中总黄酮和多糖含量进行了比较研究;②首次对番石榴幼果中的降糖成分进行研究;③通过大量的优化实验建立起番石榴叶黄酮提取纯化工艺并比较了两种中试提取方式,最终确定了适合工业生产的提取纯化工艺;④利用番石榴叶黄酮提取物开发出一种降糖药物组合并申请了专利。更多还原

【Abstract】 Guava (Psidium guajava Linn1) belongs in Myrtaceae. Other names of guava are Fan Ren, Jishi Fruit, Fan Tao. They are firstly found in tropical America, and are distributed in tropical and subtropical regions of the world, and are in the wild area or near the village. They are cultivated in Guangxi, Guangdong, Fujian, Sichuan and Jiangxi provinces in China, and rich in Taiwan.There will produce by-products that are unripe fruits and leaves in the process of planting guava. Both of there two by-products can be used as medicine, the main effect that is recorded in Guangdong Chinese herbal medicine standard have astringing intestinal, stopping diarrhea, stanching bleeding c. According to the literature, people have long used guava to lower blood sugar. In a nearly dozen years , It is showed that the flavonoids and polysaccharides of guava have hypoglycemic effects, after researchers completed a large number of experiments. Unripe fruits and leaves are developed into healthy products to turn waste into treasure.The study objects of the project are unripe fruits and leaves that are by-products generated in the process of planting guava. With their hypoglycemic effect as an entry point, we study the extraction process of their hypoglycemic components—total flavonoids and total polysaccharides, and develop products whose raw materials are unripe fruits and leaves of guava. The content of study include:①study on detection methods of total flavonoids and total polysaccharides in guava leaves and unripe fruits;②study on total flavonoids and total polysaccharides content in different regions and different varieties of guava leaves and unripe fruits in Guangzhou;③preliminary study on the extraction process of hypoglycemic components in guava unripe fruits;④study on optimizing the extraction and purification process of total flavonoids in guava leaves in the laboratory and pilot scale test;⑤verification tests on hypoglycemic effects of unripe fruits water extract and guava leaves flavonoids extract.Innovation points of this project are:①Firstly studying total flavonoids and total polysaccharides content in different regions and different varieties of guava leaves and unripe fruits in Guangzhou;②firstly studying hypoglycemic components in guava unripe fruits ;③ setting up the optimized extraction and purification process of total flavonoids in guava leaves by a large number of experiments and comparing the two pilot extraction method, and ultimately determining the industrial appropriate extraction and purification process;④developing a hypoglycemic drug combination containing guava leaves flavonoids extract, and applying for a patent.更多还原