【作者】 胡倩；

【导师】 张文华；

【作者基本信息】 大连医科大学 ， 影像医学与核医学， 2011， 硕士

【摘要】 目的:应用超声脉冲多普勒(PW)、组织多普勒成像(TDI)联合技术评价甲亢性心脏病(简称甲亢心)右室功能。方法:选取60例甲状腺功能亢进(简称甲亢)患者,根据是否并发甲亢心分为单纯甲亢组(37例)和甲亢心组(23例),并选取30例正常人为对照组,应用PW测量三尖瓣口舒张期峰值血流速度E峰;应用TDI于心尖四腔切面三尖瓣环间隔处和侧壁处测量收缩期峰值速度(Sm)、舒张期峰值速度(Em),并计算E/Em。结果:⑴与对照组比较,单纯甲亢组侧壁处Sm增高,两组之间差异有统计学意义(P﹤0.05),甲亢心组侧壁处Sm较单纯甲亢组差异有统计学意义(P﹤0.05);⑵甲亢心组侧壁处Em减低,较对照组差异有统计学意义(P﹤0.05);⑶单纯甲亢组侧壁处E/Em与对照组之间差异无统计学意义(P﹥0.05),而甲亢心组较对照组E/Em明显增高,两组之间差异有统计学意义(P﹤0.05)。结论:PW与TDI联合应用可以较为准确地评价甲亢心患者右室功能。目的:探讨超声背向散射积分参数(IBS)在评价甲状腺功能亢进(甲亢)导致肝脏损害方面的临床应用价值。方法:实验组为60例甲亢患者(未经药物治疗),分为单纯性甲亢组(29例肝生化正常患者),甲亢性肝损害组(31例肝功能指标异常患者),对照组为50例健康成人。对三组受试者肝脏进行超声IBS参数测定,同时所有受检者均静脉采血进行甲状腺功能及肝功能指标测定。结果:实验组肝脏IBS及IBS%均较对照组显著增高(P<0.01);甲亢性肝损害组中出现肝脏损伤较单纯甲亢组未出现肝脏损伤者肝脏IBS及IBS%增高(P<0.05);相关分析示游离四碘甲状腺原氨酸(FT4)与谷丙转氨酶(ALT)、碱性磷酸酶(ALP)呈正相关(r1=0.501、r2=0.558, P<0.05)。肝脏IBS%与ALP、ALT、FT4均呈正相关(r1=0.702、r2=0.617、r3=0.604,P<0.05)。结论:超声背向散射积分参数可以定量评价甲状腺功能亢进所致的肝脏损害,尤其是对肝脏的早期损伤的评价较临床更为敏感。更多还原

【Abstract】 Objective:To evaluate the right ventricular function in patients with hyperthyroid cardiopathy by pulse ultrasonic wave Doppler technique (PW) and Tissue Doppler imaging (TDI).Methods: Sixty patients having hyperthyroidism,whether they have hyperthyroid cardiopathy or not divided into simple hyperthyroidism group(n=37) and hyperthyroid cardiopathy group(n=23).Thirty normal volunteers served as control group.Tricuspid inflow velocity(E) was measured by Doppler echocardiography;TDI-derived systolic tricuspid annular velocity(Sm),diastolic tricuspid annular velocity(Em),the ratio of diastolic tricuspid inflow velocity to Em (E/Em) was caculated.Results:①Compared with control group,Sm was higher in simple hyperthyroidism group(P﹤0.05),Compared with simple hyperthyroidism group, Sm was lower in cardiopathy group(P﹤0.05).②Compared with control group,Em of tricuspid annular lateral wall was lower in hyperthyroid cardiopathy group(P﹤0.05).③The E/Em ratio in hyperthyroid cardiopathy group was significantly higher than that in control group(P﹤0.05),however there were no significant differences between simple hyperthyroidism group and control group(P﹤0.05).Conclusion:PW and TDI can exactly evaluate right ventricular function in patients with hyperthyroid cardiopathy. Objective: To evaluate the clinical value of integrated backscatter(IBS) parameters in hyperthyroidism with hepatic dysfunction.Methods: Sixty patients having hyperthyroidism haven’t take medicine yet divided into normal Liver biochemical group(n=29)and abnormal Liver biochemical group(n=31).Fifty volunteers without liver diseases(control group).Integrated backscatter parameters were detected by ultrusound.Thyroid and liver function parameter were measured by vascular blood.Results: IBS and IBS% were significantly higher in the experimental group than those in the control group (P<0.01) .IBS and IBS% in abnormal Liver biochemical group was higher than that in normal Liver biochemical group(P﹤0.05).Correlation analysis:there is positive correlation between FT4 and ALP,ALT(r1=0.501、r2=0.558,P<0.05).IBS% is positive correlation with ALP,ALT,FT4.(r1=0.702、r2=0.617、r3=0.604,P<0.05).Conclusion: Integrated backscatter parameters may be valuable in the assessment of hyperthyroidism with hepatic dysfunction,especially in the assessment of early damage.更多还原