【作者】 郭敏；

【导师】 孙圣刚；

【作者基本信息】 华中科技大学 ， 神经科， 2011， 硕士

【摘要】 目的分别对正在接受深部脑刺激(Deep brain stimulation, DBS)治疗的帕金森病(Parkinson’s disease,PD)患者与接受单纯药物治疗的PD患者进行非运动症状综合评估和对照分析,探讨DBS治疗对PD患者非运动症状的影响。方法随机选取25例正在接受DBS治疗的PD患者(DBS组)及25例接受单纯药物治疗的PD患者(药物组),分别进行问卷式调查。运动功能的测验工具是统一帕金森病评定量表Ⅲ部分(UPDRSⅢ);非运动症状测验工具包括简易精神状态量表(MMSE)、修订的阿尔茨海默病评定量表-认知(ADAS-cog)、汉密尔顿(HAMD)和抑郁量表(CES-D)以及PSQI匹兹堡睡眠质量指数、NF疲劳量表,便秘量表分别对认知功能、抑郁、睡眠障碍、疲劳和便秘进行评价。结果与单纯服用抗帕金森药物的PD患者相比,接受双侧丘脑底核(Subthalamic Nucleus, STN)DBS治疗的PD患者在UPDRSⅢ有明显改善(P<0.001);HAMD、CES-D量表结果显示接受DBS治疗的PD患者抑郁程度和发生频度亦有明显改善(P<0.05);PSQI、NF量表评分也有显著改善(P<0.05);MMSE、ADAS-cog与便秘量表DBS组与药物组评分无明显差异。相关性分析显示运动功能的改善能显著影响抑郁程度(r=0.725)和发生频度(r=0.651)(P<0.05)。结论DBS术能显著改善PD患者的运动功能,进一步影响抑郁、睡眠功能,从而改善非运动症状。更多还原

【Abstract】 ObectiveTo respectively evaluate and contrast analysis the non-motor symtoms of patients with Parkinson’s Disease (PD) undergoing deep brain stimulation(DBS)therapy and simple drug treament, observe the motor function and non-motor symtoms improvement of DBS therapy on PDpatients.MethodsTwenty-five patients with PD were included in a paired design study. The patients were randomly divided into DBS and anti- Parkinson’s medication control groups , surveied by a questionnaire-type. Motor fluctuation and dyskinesia assessment was by the Unified Parkinson Disease Rating Scale PartⅢ; non-motor symtoms assessment included the Mini Mental State Examination (MMSE), Alzheimer’s Disease Rating Scale Revised-Cognitive (ADAS-cog), Hamilton (HAMD) and the Center for Epidemiologic Studies Depression Scale (CES-D); Pittsburgh sleep quality index ( PSQI ), Fatigue Scale (NF) and Constipation Scale.ResultsCompared with the medication control group, significant benefit was obtained in motor manifestations(UPDRS section3, P<0.001) of the DBS group, and its PSQI, NF HAMD and CES-D (P<0.05), without MMSE、ADAS-cog and Constipation Scale .Correlation analysis showed that Motor function could impact the extent and frequency of depression. Conclusions In the accordance with our results, DBS significantly improved the motor function and depression, the quality of sleep important aspects with advanced PD.更多还原