【作者】 尹花；

【导师】 金英子；

【作者基本信息】 延边大学 ， 妇产科学， 2011， 硕士

【摘要】 目的通过对延边地区孕妇支原体(UU)、衣原体(CT)、B族溶血性链球菌(GBS)感染与胎膜早破(PROM)的关系及其不良妊娠结局的研究,寻找临床上预防和治疗胎膜早破的途径,以便进一步做好围产期保健,促进母儿健康,提高妊娠质量。方法选择2010年11月初至2011年4月末在延边大学附属医院妇产科住院患者190例,其中胎膜早破孕妇114例(观察组),未胎膜早破正常孕妇76例(对照组)。取宫颈管分泌物,进行解尿支原体、沙眼衣原体、B族溶血性链球菌培养、检测和胎膜病理检测,从而研究支原体、衣原体、B族溶血性链球菌感染与胎膜早破及其不良妊娠结局之间的关系。结果1、胎膜早破与未胎膜早破病例,解尿支原体感染率之间有显著性差异。2、胎膜早破病例的解尿支原体感染率高达49.12%,其中足月前胎膜早破的解尿支原体感染率(57.58%)明显高于足月胎膜早破(37.50%),两者之间有显著性差异。3、胎膜早破与未胎膜早破病例,绒毛膜羊膜炎患病率之间有显著性差异。4、解尿支原体感染病例,早产、新生儿窒息发病率明显高于未感染病例。5、沙眼衣原体、B族溶血性链球菌感染病例,围产儿死亡率明显高于未感染病例。6、本地区朝汉孕妇解尿支原体感染率之间无显著性差异。结论1、孕妇生殖道解尿支原体感染是导致胎膜早破的重要因素。而且是足月前胎膜早破的重要原因。孕前及孕期常规多次检测及治疗生殖道解尿支原体感染是预防早产的重要途径。2、解尿支原体感染导致胎膜早破的机制并不是通过绒毛膜羊膜炎,可能是其他途径。3、本地区孕妇沙眼衣原体、B族溶血性链球菌感染率极低,并不是导致胎膜早破的重要感染致病菌。4、孕妇沙眼衣原体、B族溶血性链球菌感染与绒毛膜羊膜炎有关。5、沙眼衣原体、B族溶血性链球菌感染率低,但一旦感染,围生儿预后差。更多还原

【Abstract】 Objective:To study Correlation of Ureaplasma urealyticum (UU), Chlamydia(CT), Sroup B streptococcus(GBS) infection of gravida and premature rupture of membrane(PROM) in yanbian areas, Looking for clinical prophylaxis and treatment of premature rupture of membrane, further work perinatal care, to promote the health of the mother and the children, to increase pregnancy quality.Method:Selection in November 2010-April 2011 at the obstetrics and gynecology in YanBian university hospital in-patient obstetric delivery in pregnant women 114 cases of premature rupture of membranes(observation group)and 76 cases of full—term pregnancy, premature rupture of membranes without labor(NPROM) hospitalized pregnant women (control group)of cervical secretions for Ureaplasma urealyticum (UU), Chlamydia(CT), Group B streptococcus (GBS) to cultivation and fetal membranes pathology detection, and analysis of the outcome of pregnancy.Result:1、Ureaplasma urealyticum (UU) infection rates of premature rupture of membrane is higher than womb not tire premature rupture of membrane cases.2、Ureaplasma urealyticum (UU) infection rates of preterm PROM(57.58%) is higher than full—term pregnancy PROM(37.50%), that have significant differences.3、Premature rupture of membranes and womb not tire premature rupture of membrane cases, differentiate between amniotic membrane infection rates were significantly different.4、Ureaplasma urealyticum (UU) infection is related premature delivery and neonatal asphyxia, isn’t related HCA, amniotic fluid pollution and postpartum hemorrhage.5、Chlamydia(CT) and Group B streptococcus (GBS) infection is related perinatal mortality rate.6、Ureaplasma urealyticum (UU) infection rates of chao and han gravidaum have not significant differences.Conclusion:1、Ureaplasma urealyticum (UU) of gravida infection is premature rupture of membranes (PROM) important factor, furthermore that is preterm delivery PROM important reason.2、mechanism of Ureaplasma urealyticum (UU) infection causes PROM isn’t related to chorioamnionitis.3、Chlamydia(CT) and Group B streptococcus (GBS) of YanBian gravida infection rates is lower, that isn’t important infection pathogenic bacteria of PROM.4、Chlamydia(CT) and Group B streptococcus (GBS) infection of gravida is related chorioamnitis.5、Chlamydia(CT) and Group B streptococcus(GBS) infection rates is low, but it infect, that perinatal mortality prognosis is poor.更多还原