【作者】 瞿湘梅；

【导师】 杨宗孟；

【作者基本信息】 长春中医药大学 ， 中西医结合临床， 2011， 硕士

【摘要】 目的:通过观察二仙汤加减治疗卵巢早衰的临床疗效,从改善围绝经期症状、血清内分泌激素FSH、LH、E₂的变化及改善卵巢储备功能等方面,为临床治疗该病提供依据。方法:将60名符合标准的卵巢早衰患者按随机分组原则均分为治疗组和对照组,两组病例数均为30例,疗程相同（3个月为1个疗程,连续2个疗程）。分别观察治疗组和对照组在治疗前后的临床症状改变、月经来潮情况,并于治疗前和治疗结束3个月（如逢月经来潮则在月经周期第3天）检测血清性激素（FSH、LH、E₂）,并观察两组中抗苗勒管激素AMH及抗卵巢抗体AOAb,将两组得出的数据进行对比分析。结果:①治疗组和对照组临床疗效的总有效率分别为86.67%、90.00%;在提高苗勒氏管抑制物AMH和改善卵巢自身免疫抗卵巢抗体AOAb方面,治疗组均明显优于对照组,（P<0.05）。②两组在改善POF患者的围绝经期的症状有明显差异,治疗组尤其在改善烘热汗出、头晕耳鸣、腰膝酸软、畏寒肢冷、倦怠乏力等症状方面优于对照组。③在促进FSH下降、E₂上升均有极显著性差异（P<0.01）,两组间疗效对比差异有显著性（P<0.05）,说明治疗组对促进雌激素分泌优于对照组。结论:两组方法在临床上都取得了较好的疗效。经临床观察及对比分析后发现治疗组在促进性激素分泌、临床症状的改善方面优于对照组,且能明显提高卵巢储备功能,改善卵巢自身免疫。说明二仙汤加减治疗卵巢早衰有确切疗效又安全可靠,并能明显改善卵巢储备功能具有一定的临床推广价值。更多还原

【Abstract】 Objective: Through the observation two fairy tonga reduce premature aging of the clinical effect of treatment ovarian, from perimenopausal symptoms improve, serum endocrine hormone FSH and LH, E₂ change and improvement of ovarian function, reserve for clinical treatment provides the basis for the disease.Methods: 60 standard ovarian grouping principle according to random premature senility patients were divided into treatment group and control group, two groups of cases are 30 cases, the same treatment （3 months for a period of treatment, two consecutive period of treatment）. The treatment group and control group were observed before and after treatment in the clinical symptoms change, menstrual cramps, and in the end of therapy before treatment and 3 months （such as wel menstrual cramps in menstrual cycle is the third day） test （FSH and LH serum sex hormones, E₂）, and looking at the two groups of resistant mullerian tube hormone AMH and resistance to ovarian antibody AOAb, two groups of data that will were analyzed.Results: （1） the treatment group and control group clinical curative effect of the total effective rate was 86.67%, 90.00%; In improving mullerian’s tube inhibit content and improve their own immune AMH ovarian AOAb aspects of ovarian antibody, the treatment group were significantly better than control group, （P < 0.05）. （2） the two groups of patients improve POF perimenopausal symptoms have obvious difference, the treatment group especially in improving the sweat out, dizziness tinnitus, waist sour leg soft, chills limb cold, burnout, such as the lack of the symptoms than control group. （3） in promoting FSH decline, E₂ rise all have significantly difference （P < 0.01） between the two groups, the difference was obvious contrast effect （P < 0.05）, indicating that the treatment group than in control group to promote the secretion of estrogen.Conclusion: two groups have clinical methods in the good effect. The clinical observation and comparison analysis found that the treatment group in promoting the secretion of clinical symptoms, estrogen improvement of better than control group, and can obviously improve the ovarian function reserves. Explain two fairy tonga reduce premature aging treatment of ovarian effective exactly and safe and reliable, and can improve the ovarian function reserves has certain clinical value of popularization.更多还原