【作者】 闫珺；

【导师】 刘松江；

【作者基本信息】 黑龙江中医药大学 ， 中西医结合临床， 2011， 硕士

【摘要】 目的：通过观察培元抑瘤汤联合吉西他滨(GEM)单药化疗治疗老年晚期非小细胞肺癌(NSCLC)的临床疗效,为中西医结合治疗老年晚期NSCLC的研究提供理论依据,为研制新的抗癌中药制剂奠定临床基础。方法：选择老年晚期NSCLC患者52例,随机分为治疗组(中药加化疗组)26例,对照组(单纯化疗组)26例。治疗组采用培元抑瘤汤联合GEM(吉西他滨)单药化疗,对照组采用GEM单药化疗,连续观察3周期,每周期21天。比较两组治疗前后血清肿瘤标志物CEA变化、临床主要症状、生存质量改善情况及主要不良反应的发生率。结果：治疗组在降低血清肿瘤标记物(CEA)、改善患者临床症状及提高患者生存质量方面与对照组比较有显著差异(P<0.05)。在不良反应发生率方面,白细胞(WBC)减少、血小板(PLT)减少、恶心呕吐发生率方面两组比较,有显著差异(P<0.05)；其余指标无显著差异(P>0.05)。结论：1.培元抑瘤汤联合吉西他滨单药化疗可以降低血清CEA水平。2.培元抑瘤汤联合吉西他滨单药化疗可以明显改善患者临床症状,提高生存质量。3.培元抑瘤汤可以降低吉西他滨引起的骨髓抑制、恶心呕吐的发生率,对肝肾功无不良影响。更多还原

【Abstract】 Object:It is a research aimed at fifty-two senile patients suffered from advanced NSCLC who accepted a two-months therapy using chemotherapy treatment and decoction. Treatment evaluation would be acquired through observing several different indexes of those patients.Methods:Patients were divided into two groups named control group and therapy group at random. The former accepted chemotherapy treatment (GEM), and the latter accepted chemotherapy treatment (GEM) and decoction (Peiyuanyiliu Decoction). Tumor indicators (CEA), symptoms, quality of life and side effects would be recorded during the whole therapeutic process.Results:Significant differences were founded between two groups in tumor indicators (CEA), symptoms, quality of life and most side effects. But little differences were founded in Glutam ic-oxaloacetic transaminase and Glutamic-pyruvic transamin ase.Conclusions:1.The association of GEM and Peiyuanyiliu Decoction could reduce the level of CEA.2. The integration of GEM and Peiyuanyiliu Decoction could significantly alleviate symptoms and enhance the quality patients’ life.3. The association of GEM and Peiyuanyiliu Decoction could reduce side effects caused by GEM.更多还原