【作者】 袁东；

【导师】 王兴华；

【作者基本信息】 南京中医药大学 ， 中医临床基础， 2010， 硕士

【摘要】 目的：观察健脾化湿祛瘀解毒方对晚期大肠癌的治疗效果,并探讨其机理。方法：选择晚期大肠癌患者30例,随机分为治疗组15例,服用健脾化湿祛瘀解毒方,并联合FOLFOX方案化疗；对照组15例,单纯予FOLFOX方案化疗。比较两组患者临床症状的缓解、治疗前后一般状况的改善、血清肿瘤标志物的变化及化疗不良反应的程度,进行量化评分作为疗效评价指标,并统计分析两组在上述指标方面的差异。结果：治疗组的中医证候疗效有效率为86.67%,对照组有效率为60.00%,两组在统计学上有显著差异(P<0.05),说明治疗组在缓解临床症状方面的疗效明显优于对照组。两组患者治疗前的卡氏评分无统计学差异,但在治疗后两组的卡氏评分显示有统计学差异(P<0.05),说明治疗组在改善患者一般状况方面要优于对照组。CEA对大肠癌有一定的诊断意义,两组患者治疗前CEA值组间比较无显著性差异,在治疗后比较显示出有统计学差异,说明治疗组在降低CEA值方面较对照组也有一定优势。治疗组的肿瘤近期客观疗效有效率为33.33%,略好于对照组20.00%。两组比较无统计学差异(P>0.05)。结论：健脾化湿祛瘀解毒方在晚期大肠癌的治疗中,具有改善临床症状和机体一般状况、减轻化疗副反应等作用,值得临床推广。更多还原

【Abstract】 Object:To observe the clinic effect of Jian Pi Hua Shi Qu Yu Jie Du decoction in the treatment of advanced colorectal tumor.Method:30 cases of advanced colorectal tumor were chosen and randomly divided into two groups,15 cases of trail group were treated with Jian Pi Hua Shi Qu Yu Jie Du decoction and chemotherapy with FOLFOX scheme another 15 cases of control group were treated with chemotherapy with the same scheme only.Compare the two groups in clinical symptom amelioration,the level of serum CEA,degree of side effects caused by chemotherapy and physical strength,and count out the difference in the upper aspects between the two groups.Result:The effective rate of Chinese medicine syndrome evaluation in trail group is 86.67%,the rate of control group is 60.00%.Two groups have Statistically significant differences(p<0.05).It states that the trail group has more prominent advantage than the control group in terms of Relieving clinical symptoms. The KPS before the treatment of two groups’patients have no statistically significant differences. However, the KPS after the treatment of two groups’patients have statistically significant differences(p<0.05).It shows that the trail group has more advantages than the control group in aspect of improving general conditions of patients. CEA has the particular evaluation in diagnosing colorectal cancer.CEA before the treatment of two groups’patients have no statistically significant differences. However, CEA after the treatment of two groups’patients has statistically significant differences. It demonstrate that the trail group also has more advantages than the control group in aspect of reducing CEA value. Recent objective efficiency of curing tumor in the trail group is 33.33%.It is a bit higher than the control group (20.00%).Two groups have no statistically significant differences (p>0.05).Conclusion:In the treatment of advanced colorectal tumor, Jian Pi Hua Shi Qu Yu Jie Du decoction proved it’s function in enhancing the effect of chemotherapy, relieving the toxic and side effects caused by chemotherapy, improving the immune function, ameliorating living quantity and prolonging the life span.更多还原