【作者】 薛春燕；

【导师】 时燕萍；

【作者基本信息】 南京中医药大学 ， 中西医结合， 2011， 硕士

【摘要】 目的：本研究为运用中医古方滋肾生肝饮加减治疗肝经郁火型青春期多囊卵巢综合征的临床研究。经中药治疗,通过比较治疗前后患者的月经、中医症候等临床症状,以及性激素、B超等实验室检查指标变化,探讨加减滋肾生肝饮治疗肝经郁火型青春期多囊卵巢综合征的临床疗效,并阐明性激素结合球蛋白与青春期多囊卵巢综合征发病机制之间的关系。方法：42例证属肝经郁火型青春期多囊卵巢综合征患者,服用中药“滋肾生肝饮”加减方,3月为一个疗程。在治疗前及治疗3个月后,于月经第3天采集空腹静脉血,测定血清性激素结合球蛋白（SHBG）、睾酮（T）、黄体生成素（LH）、卵泡刺激素（FSH）、雌二醇（E₂）等,并观察月经、中医症候、体重、基础体温（BBT）等变化。结果：中药加减滋肾生肝饮治疗肝经郁火型青春期PCOS患者42例,总有效率为64.29%。治疗后月经评分较前下降41.32%,中医症候评分较前下降51.72%,统计学差异具有显著性（P<0.05）。性激素水平、基础体温（BBT）、体重指数（BMI）等方面也疗效显著（P<0.05）结论：通过本研究,证实加减滋肾生肝饮能明显改善肝经郁火型青春期多囊卵巢综合征患者的临床症状,临床应用无明显副反应,值得进一步研究和推广。其作用机制可能为通过降低体内T水平、调节脂代谢,促进SHBG与T、E2、胰岛素等激素水平间的动态平衡,以及使PCOS患者下丘脑-垂体-卵巢轴的功能得到调整恢复,整体上改善内分泌环境,调整月经周期。更多还原

【Abstract】 Purpose:This study is a clinical research of treating liver meridian fermented type of adolescence polycystic ovarian syndrome by using traditional chinese medicine Ancient formula "add and subtract zishenshenggan drink". Through the comparison of patients before and after the treatment of menstruation, TCM clinical symptoms, such as sickness, type-b ultrasonic sex hormones, discusses laboratory indicators in addition and subtraction born AIDS treatment of liver kidney by liver drink depressed fire type adolescence, the clinical curative effect of polycystic ovarian syndrome, explore zishenshenggan drink treatment liver meridian fermented type of adolescence polycystic ovarian syndrome, and discuss the clinical curative effect of sex hormone binding globulin and adolescence polycystic ovarian syndrome pathogenesis the relationship between them.Method:42 examples patients of liver meridian fermented type of adolescence polycystic ovarian syndrome, take herbal subtract" zishenshenggan drinking" for three months as a period of treatment. Before the treatment and three months after treatment, gather fasting blood in her menstrual the first three days, Determination of serum sex hormone binding globulin (SHBG), testosterone (T), luteinizing hormone (LH), eery follicle-stimulating hormone (FSH), estradiol (E2), and the observation of menstruation, TCM symptoms, weight, fundamental temperature (BBT) change.Result:Traditional Chinese medicine to "add and subtract zishenshenggan drink" by liver meridian fermented type of adolescence polycystic ovarian syndrome patients, with the total effective rate of 42 cases (64.29%). After treatment 41.32% menstrual score dropped earlier, TCM symptoms score dropped earlier 51.72% and statistically with significant difference (P< 0.05). Reproductive hormone levels, fundamental temperature (BBT), body mass index (BMI) etc also curative effect is significant (P<0.05).Conclusion:Through this research, confirm "add and subtract zishenshenggan drink" can significantly improve liver meridian fermented type adolescence polycystic ovarian syndrome patients with clinical symptoms and clinical application no significant side effects and deserves further research and extension. The mechanism of its action by lowering the body may be T level, adjusting lipid metabolism, promote with T SHBG, E2 and hormones such as insulin levels, and the dynamic balance between that PCOS patients hypothalamus-pituitary-adrenal axis function has been adjusted ovarian endocrine, the overall improve recovery environment and promote follicular and ovulation.更多还原