【作者】 卜文静；

【导师】 舒鹏；

【作者基本信息】 南京中医药大学 ， 中医学， 2011， 硕士

【摘要】 研究目的：研究和探讨健脾消癥汤联合化疗对晚期胃癌患者生活质量的干预作用,同时综合评价其对化疗副反应的控制及肿瘤标志物的影响。研究方法：临床观察Ⅳ期胃癌40例,分为两组,试验组(健脾消癥汤联合DCF方案化疗)20例,对照组(单纯化疗)20例。进行生活质量评分及临床、实验室疗效比较。研究结果：根据《欧洲癌症研究与治疗组织生命治疗核心量表第3版(QOL)》测评,试验组治疗后患者生活质量评分较对照组明显降低,经统计学分析,有显著性差异(P<0.05)；试验组治疗前后生活质量改善有效率为65%,显著高于对照组,差异有统计学意义(P<0.05)。试验组症状改善有效率70.00%,明显高于对照组,差异有统计学意义(P<0.05)。试验组出现Ⅰ度、Ⅱ度、Ⅲ度、Ⅵ度骨髓抑制的例数及骨髓抑制总发生率均低于对照组,差异有统计学意义(P<0.05)。治疗后两组ALT、TBil比较,试验组出现Ⅰ度、Ⅱ度、Ⅲ度肝功能损害的例数及肝损的总发生率均低于对照组,差异有统计学意义(P<0.05)。研究结论：健脾消癥汤联合化疗能在一定程度上提高晚期胃癌患者生活质量,改善晚期胃癌患者临床症状,减轻部分化疗的毒副作用。更多还原

【Abstract】 Objective:To evaluate the effect on quality of life(QOL) in advanced gastric cancer patients treated by Jian Pi Xiao Zheng Tang combined with DCF regimen. The side effects of chemotherapy and the tumor markers were also observed.Methods:forty patients of advanced gastric cancer were randomly divided into two groups:test group (n=20) received Jian Pi Xiao Zheng Tang and chemotherapy, and control group (n=20) only accepted chemotherapy. The QOL were compared in two groups.Result:After treatment, the QOL score of test group was significantly lower than that of control group, the difference has meaning in the statistics (P<0.05). The effective rate of the test group was 65.00%, which was significantly higher compared with the control group, the difference also has meaning in the statistics (P<0.05) In symptom improvement, the effective rate of the test group was 70.00%, significantly higher than that of the control group. The number of cases of appearing ’Ⅰ°,Ⅱ°,Ⅲ°,Ⅵ°bone marrow suppression and the overall incidence of bone marrow suppression in test group were lower than that in the control group, the difference has meaning in the statistics (P<0.05) By detecting ALT/TBil expression, in the two groups, the number of cases of appearingⅠ°,Ⅱ°,Ⅲ°,liver damage and overall incidence of liver damage in the test group were lower than that in the control group after treatment, the difference makes sense in the statistics(P<0.05).Conclusion:Jian Pi Xiao Zheng Tang combined with chemotherapy is an effective method in treating advanced gastric cancer. It can improve the quality of life and alleviate the clinical symptoms, reduce the side effects of chemotherapy.更多还原