【作者】 李乐；

【导师】 张维录；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2011， 硕士

【摘要】 目的:观察肺部疾病炎症早期(痰浊壅肺证)应用活血化瘀药物的临床疗效并探讨其作用机制。方法:将符合本研究标准的60例患者按照随机、对照的原则分为试验组30例,对照组30例。试验组在西药常规治疗的基础上加用中成药制剂,静滴,每日一次。对照组西药常规治疗。观察两组患者综合疗效、死亡人数、达到目标疗效天数、证候学疗效、治疗前后血液学指标、不良反应等。结果:两者在综合疗效、死亡人数方面无显著差异(p>0.05),但达到目标疗效天数(p<0.01)试验组与对照组相比明显缩短,同样治疗时间内,证候学疗效评定(p<0.01)试验组优于对照组,血液学指标复常情况(p<0.05)试验组优于对照组。结论:活血化瘀药应用于炎症早期,可以显著改善患者临床症状,控制炎症反应程度。与西医常规药联合应用,可以提高疗效,缩短疗程。其机理可能与活血化瘀药物调节免疫力、抗氧化、清除炎性因子、保护血管内皮细胞、改善微循环及供氧等作用有关。更多还原

【Abstract】 Objective: to observe the clinical efficacy of drug for promoting blood circulation and removing stasis in the early stage of pulmonary diseases’inflammation(that is, syndrome of turbid phlegm obstructing lung), and explore its mechanism of action.Methods: according to the principle of random and control, to divide the 60 patients complying with the standard of this research into two groups: 30 people in experimental group and 30 in control group. Treat the experimental group with Chinese medicines on the basis of conventional therapy with western medicine, using intravenous drip once a day. Meanwhile, treat the control group with western medicine only in conventional therapy. To observe the clinical general therapheutic effect, the death amount, the time to reach the objective effect, the syndrome effects, the hematology index before and after the cure and the untoward effects of all patients, and find out the result is: patients of two groups have no significant difference in clinical general therapheutic effect and death amount(p>0.05). But on the time to reach to the objective effect, experimental group(p<0.01) is significantly short than control group. And in the equal period of cure, experimental group’s syndrome effects of (p<0.01) and hematology index are all better than control group.Conclusion: drug for promoting blood circulation and removing stasis should be applied into the early stage of inflammation, which can noticeably improve patients’clinical efficacy and control the reaction degree of inflammation. To combine western medicines with Chinese medicines together into disease cure can promote clinical effectiveness and shorten time of treatment. The mechanism of the above phenomenon may lie in the remakable healing efficacy of drug for promoting blood circulation and removing stasis on enhancing immunity, resisting oxidation, clearing inflammatory factor, protecting vascular endothelial cells, improving the microcirculation and and supplying oxygen and so on.更多还原