【作者】 张新；

【导师】 曹志群；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2011， 硕士

【摘要】 目的:本研究旨在探讨溃疡性结肠炎(ulcerative colitis UC)患者伴抑郁、焦虑的相关因素以及与中医证候之间的相关性。方法:运用流行病学的方法,收集溃疡性结肠炎患者的基本信息及相关中医证候信息,并进行抑郁、焦虑自评量表测试,将所得资料进行统计分析,找出流行病学资料、影响发病的相关因素和中医证候学规律及其与抑郁、焦虑的相关性。结果:1.将患者抑郁、焦虑自评量表评分与国内常模比较,提示UC与抑郁、焦虑显著相关。2.经χ~2检验及Logistic回归分析,得出女性、性格内向、工作生活压力大、情志刺激为UC伴抑郁发病的危险因素;女性、性格内向、工作生活压力大、年龄在40-49岁之间为UC伴焦虑发病的危险因素。3.应用直线回归,症状积分分别与SDS量表、SAS量表评分比较,两组变量间高度正相关。4.经χ~2检验及Logistic回归分析,UC伴抑郁、焦虑与中医证候分布之间的差异有统计学意义。肝郁脾虚证、脾胃虚弱证与UC伴抑郁的发病有关;湿热内蕴证与UC伴焦虑的发病有关。结论:1.UC与抑郁、焦虑明显相关。2.随着UC症状积分的增大,患者抑郁、焦虑的程度越重。3.女性、性格内向、工作生活压力大、受到情志刺激的UC患者易患抑郁;女性、性格内向、工作生活压力大、年龄在40-49岁之间的UC患者易患焦虑。4.中医证候分型为肝郁脾虚证、脾胃虚弱证的UC患者易患抑郁。中医证候分型为湿热内蕴证的UC患者易患焦虑。更多还原

【Abstract】 Objective:This study aims at exploring the interrelation between ulcerative colitis and depression and anxiety, and finding out the regularity among common syndromes of ulcerative colitis in TCM. Methods: Using the method of epidemiological survey, basic data and clinical informations of patients with ulcerative colitis were collected, additionally, the patients were asked to assess their severity of depression and anxiety and also fill in questionnaire; and finally all the above data and information were processed and analyzed to find out epidemiological data, potential pathogenic factors and interrelation between syndrome and depression and/or anxiety. Result: 1. The study has shown the incidence of ulcerative colitis is closely interralated with depression and anxiety.2 .With the methods ofχ2 test and Logistic regression analysis, the study suggested that some factors such as female , introverted personality and stress can be considered as potential factors leading to ulcerative colitis , the patients at ages between 40-49 in particular. 3. The study showed significant differences in statistics between the patients accompanied by depression and anxiety, and their common syndromes .4.The patients accompanied with depression were often manifested as the syndrome of‘stagnation of the liver with deficiency of the spleen’, or‘deficiency of the spleen and stomach; whilst the patients accompanied by anxiety were mostly marked by the syndrome of‘internal accumulation of dampness and heat’. Conclusion: 1. Pathogenically, ulcerative colitis is obviously interralated with depression and anxiety.2. Clinically, along with the development and deterioration of ulcerative colitis, depression and anxiety became more and more serious. 3. In the patients with ulcerative colitis, depression often occurred in cases of female, introverted personality, and stress due to work and life; while anxiety was mostly seen in cases of female, introverted personality, severe stress caused by work and life, ages at 40-49 in particular. 4. The patient accompanied with depression mostly showed in the syndrome of‘stagnation of the liver and deficiency of spleen’or‘deficiency of the spleen and stomach’; while the patients accompanied by anxiety were often seen in the syndrome of‘internal accumulation of dampness and heat’.更多还原