【作者】 蔡侃；

【导师】 张娟；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2011， 硕士

【摘要】 目的:通过临床病例观察和动物实验研究健脾疏肝饮治疗糖尿病胃轻瘫(Diabetic Gastro Paresis.DGP)的疗效。方法:1.临床观察:将60例DGP患者随机分为试验组与对照组各30例。在基础治疗前提下,试验组给予疏肝健脾饮汤剂(基本方为:柴胡,白芍,枳实,党参,黄芪,白术,姜半夏,黄连,生姜,厚朴,木香,当归,炙甘草。)口服;对照组予吗丁啉口服。以临床症状积分、空腹和餐后2h血糖以及糖化血红蛋白等为评价标准,通过与对照组的比较讨论疗效。2.动物实验:建立糖尿病胃轻瘫大鼠动物模型,给予中药或生理盐水灌胃8周后,通过模型组,中药组和正常组的阳性神经免疫组化染色比较,讨论健脾疏肝饮的疗效。结果:1.临床观察:治疗组总有效率为93.3%,对照组总有效率为76.7%。两组在治疗后症状总积分上有显著差异(P<0.01),单独症状积分比较显示:两组在治疗早饱、胃脘胀满、嘈杂、纳呆的疗效相当(P>0.05)。而治疗组对DGP患者嗳气、倦怠乏力、恶心、情志不舒等的疗效较对照组有优势(P<0.05)。2.动物实验:8周后大鼠胃窦肌间神经丛中nNOS、5-HT4R染色阳性神经平均灰度值,中药组与模型组、熟地组有显著差异(P<0.01);而它们与正常组比较无明显差异(P> 0.05);表明健脾疏肝饮可对糖尿病大鼠胃窦肌间神经丛有保护作用。结论:疏肝健脾饮在治疗糖尿病胃轻瘫方面有良好的疗效,有临床应用前景。更多还原

【Abstract】 Objective:To observe the therapeutic effect of traditional Chinese medicine on diabetic gastroparesis。Methods : Clinical research : 60 patients with diabetic grastroparesis were randomly divided into two groups.30 patients in experimental group were treated by traditional Chinese medicine;30 patients in control group were treated by single western medicine,with a treatment course of eight weeks for both groups.The therapeutic effects were evaluated after 1 treatment course.Animal Experiment:building animal models of diabetic gastro paresis,to abserve difference of nNOS、5-HT4R between the Normal group and treated group.Results:Clinical research:There was a significant difference in improvement of symptoms,and in the aspect of nausea anorexia eructation and epigastric upset.Animal Experiment: There was a significant difference in the contents of nNOS、5-HT4R of diabetic gastroparesis rats.Conclusion:Treatment of traditional Chinese medicine is effective in treating diabetic gastroparesis.更多还原