【作者】 曹越；

【导师】 徐云生；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2011， 硕士

【摘要】 目的:观察以益气温阳活血法为治则的中药对改善糖尿病周围神经病变(DPN)的临床疗效并探讨其作用机制。方法:所有患者60名均确诊为糖尿病周围神经病变。将病例随机分为2组,治疗组(30例)服用益气温阳活血汤,对照组(30例)在同样条件下给予甲钴胺胶囊0.5mg,每天3次,口服。两组均以40天为1个疗程,共治2个疗程,然后评价两组神经传导速度。结果:经临床观察,治疗组有效率为80%,对照组的有效率为63.3%。治疗组在治疗前和治疗后的神经传导速度有显著差异(p<0.05),说明此法治疗是有效的。对照组治疗前和治疗后的神经传导速度有显著差异(p<0.01),说明西药治疗也是有效的。治疗后治疗组与对照组比较神经传导速度也有显著差异(p<0.01)。说明中药与西药治疗不尽相同。治疗组对改善临床症状,提高神经传导速度方面优于对照组(p<0.05)。结论:益气温阳活血汤对治疗糖尿病周围神经病变效果优于甲钴胺胶囊。同时证明以阳虚寒凝血瘀为糖尿病周围神经病变的病机,利用益气温阳活血法治疗糖尿病周围神经病变具有可行性。更多还原

【Abstract】 Object:To observe the therapeutic efficacy of Yiqiwenyanghuoxue decoction in treating Diabetic Peripheral Neuropathy(DPN).Methods: 60 patients diagnosed DPN were randomly classified into two groups .30 patients in treated group were treated with Yiqiwenyanghuoxue decoction,others in control group were treated with Jiaguan grannules.Eighty days were a course of treatment. Result:Through observtion,there are significant effects of treatment on nerve conduction between pre-treatment and post-treatment in both TCM group(p<0.05) and WM group(p<0.01).In addition,there are also obvious difference between TCM and WM,indicating that the effects of TCM and WM were different.Conclusion:Yiqiwenyanghuoxue decoction has more curative effect than Jiaguan grannules in treating DPN,and it can prove that the freezing coldness from deficiency of yang and blood stasis is pathogenesis of DPN.To treat DPN with method of Yiqiwenyanghuoxue is feasibility.更多还原