【作者】 康卫阳；

【导师】 刘英；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2011， 硕士

【摘要】 目的:观察健脾补肾,祛瘀化痰法治疗原发痛风性关节炎慢性期的疗效,并探讨其病因。方法:采用随机、对照方法,选取60例原发痛风慢性期患者,分为试验组30例,予健脾补肾,祛瘀化痰法治疗;对照组30例,予别嘌醇治疗,观察6周,采用降尿酸疗效判定及中医症候总疗效判定标准,评价健脾补肾,祛瘀化痰法对原发痛风慢性期的治疗效果。结果:1.在降低尿酸水平上,两组之间无显著差异(P>0.05)。2.在中医症候疗效及总有效率方面,试验组优于对照组(P<0.05);在改善关节疼痛、肿胀,缓解病人肢体沉重、神疲乏力等方面,试验组优于对照组(P<0.05)。3.不良反应方面,试验组发生率为7%,对照组为10%,试验组安全性较对照组高,但两组均无严重不良反应,在对症处理后均可消失。结论:两组对原发痛风慢性期降低尿酸方面,均有良好治疗效果,但是在缓解临床症状及中医症候方面,试验组优于对照组,研究表明,健脾补肾,祛瘀化痰法治疗原发痛风慢性期,疗效好,安全性高。更多还原

【Abstract】 Objective: The efficacy on chronic phase of gouty arthritis treated with regulating and reinforcing spleen and kidney,expelling stasis and resolving phlegm following Traditional Chinese Medicine was evaluated,and the primary mechanism on how the herbal treated the disease was explored. Methods: A randomized, control method is adopted. 60 cases with chronic phase of gouty arthritis were randomized into two groups.The patients in treated group (30 cases) were administered with the herbal medicine following regulating and reinforcing spleen and kidney,expelling stasis and resolving phlegm following traditional Chinese medicine. The patients in control group (30 cases) were treated with routine therapy in Western medicine,Allopurinol. Observating 6 weeks,we evaluated the therapeutic effect of regulating and reinforcing spleen and kidney,expelling stasis,resolving phlegm stasis on chronic phase of gouty arthritis by using the curative standard and symptoms of TCM. Results:1.There is no significant difference in droping uric acid level between the two groups(P>0.05).2.The curative standard and symptoms of TCM of the treated group is superior to that of the control group(P<0.05) . The treated group is also better than the control group in improving joint pain, swelling, alleviating patient,s limbs heaviness, general lassitude,etc(P<0.05).3.The safety of the therapy in the treated group is higher than that of the control group. But there are no serious adverse reactions both in the two groups. Conclusion:There i good therapeutic effect both in the two groups in droping uric acid level. But the treated group is superior to the control group in improving TCM symptoms and alleviating clinical symptoms. So,The herbal medicine with regulating and reinforcing spleen and kidney,expelling stasis and resolving phlegm could be a safe,effective way to treat chronic phase of gouty arthritis.更多还原