【作者】 肖春霞；

【导师】 张洪亮；

【作者基本信息】 新疆医科大学 ， 中西医结合临床医学， 2011， 硕士

【摘要】 目的：通过芜菁膏治疗大肠癌FOLFOX4化疗后属脾虚湿盛型患者临床观察,探索芜菁膏在改善大肠癌联合化疗不良反应的作用,初步评估芜菁膏对大肠癌化疗病人的减毒作用。方法：入组患者76例,随机分为两组,治疗组38例,对照组38例,对照组给予FOLFOX4化疗,治疗组在对照组基础上服用芜菁膏,一日三次,每次60g,14天为一个疗程,一个疗程后判断白细胞总数及下降发生率、血红蛋白数值及下降发生率、恶心呕吐发生率、中医临床症状积分变化、卡氏评分、免疫指标测定、化疗完成率。结果：治疗组与对照组治疗前后白细胞总数均有下降(P<0.05),治疗组白细胞下降发生率较对照组低,且有统计学意义(P<0.05)；两组患者血红蛋白下降发生率及下降程度差异无统计学意义(P>0.05)；两组患者治疗后中医临床症状积分均增高,有统计学差异(P<0.05)；两组患者治疗后卡氏评分均下降,有统计学差异(P<0.05)；两组免疫指标检测均优于观察组,差异有统计学意义(P<0.05)；两组化疗完成率均大于85%,差异无统计学意义(P>0.05)。结论：1.芜菁膏能提高大肠癌FOLFOX4化疗后病人免疫指标,使得CD4、CD4/CD8、NK上升,降低CD8：降低中晚期大肠癌患者化疗后白细胞下降发生率；能提高化疗病人KPS评分。2.芜菁膏能改善化疗后患者“脾虚湿盛”临床症状。更多还原

【Abstract】 Objective:To observe the clinical effects of Wujing Ointment in educing adverse reactions and initially explore its mechanism of action by treating the patients of Cancer of Colorectum attached to Asthenia of Spleen and Pathogenic damp with FOLFOX4. Methods:76 cases who meet the diagnosis standard of Cancer of Colorectum from our co-operation hospitals were domized into two groups (38 cases respectively):the control group which FOLFOX4 only was given and the treatment group used Wujing Ointment at the same time.,60g/d, three times a day.After one cycle,we surveied the quantity and the descenting rate of WBC、the quantity and the descenting rate of Hg、incidence rate of nausea and vomit、the changes of syndromes of TCM、Karnofsky scores、immunity and completed rate of chemotherapy.Results:the WBC quantity of two group decreased after chemotherapy, the descenting rate of WBC of the treatment group is lower than the control group, and the difference was significant statistically (P<0.05); The descenting rate of Hg of two groups and the degree has no statistical difference (P> 0.05). The syndromes of TCM of two groups all increased after chemotherapy (P< 0.05).and there was different statistically (P<0.05); The Karnofsky scores of two groups all increased after chemotherapy (P<0.05).and there was a statistical difference (P<0.05); The immunity function after chemotherapy were higher than the before,and the differences were significant statistically (P<0.05). The completed rate of chemotherapy of two groups was higher than 85%, and there was no different(P>0.05).Conclusion:1.Wujing Ointment can boost patients’immunity after FOLFOX4 and can elevate CD4、CD4/CD8、NK, and reduce CD8; Wujing Ointment can lower the descenting rate of WBC; Wujing Ointment can improve the patients’KPS.2. Wujing Ointment can improve the TCM clinical symptoms of asthenia of spleen and pathogenic damp due to chemotherapy and improve the patienrts’quality of life.更多还原