【作者】 彭媛媛；

【导师】 唐勇；

【作者基本信息】 新疆医科大学 ， 肿瘤学， 2011， 硕士

【摘要】 目的：比较TF方案和FOLFOX6方案治疗晚期胃癌的疗效及不良反应。方法：回顾性分析我院54例经病理确诊的晚期胃癌患者。A组28例,采用TF化疗方案：多西他赛50mg/m2,d1；CF400 mg/m2,d1；5-FU40 mg/m2,dl,5-FU2400～3000mg/m2,CⅣ(46小时),每14天为一周期,B组26例,采用FOLFOX6方案化疗：L-OHP100 mg/m2,d1；CF400 mg/m2,d1；5.FU400 mg/m2,d1,5-FU 2400-3000 mg/m2,CⅣ(46小时),每14天为一周期,对两组的近期疗效、生活质量改善情况、总生存期、无疾病进展时间、不良反应进行比较。结果：A组和B组的有效率分别为46.40%和46.20%,差异无统计学意义(P=0.99)。A组和B组的无疾病进展时间分别为5.5月,差异无统计学意义(P=0.54)。中位生存时间分别8.0月和8.5月,差异无统计学意义(P=0.71),A组和B组的生活质量改善为64.3%和30.80%差异有统计学意义(P=0.04)；两组主要不良反应白细胞减少、血红蛋白减少、恶心、呕吐、便秘等指标的差异具有显著性(P<0.05)。结论：TF方案和FOLFOX6方案在晚期胃癌的治疗方面近期疗效比较好,在不良反应以及生活质量改善情况等方面,TF方案优于FOLFOX6方案,具有更好的耐受性。更多还原

【Abstract】 Objective:To compare the efficacy and toxicity of TF regimen and FOLFOX6 regimen on advanced gastric carcinoma (AGG) in gastric cancer. Methods:Retrospective analysis of 54 cases confirmed by pathology in patients with advanced gastric cancer,28 patients in group A treated with DF regimen:Docetaxel 50mg/m2,d1;CF400mg/m2,d1;5-FU400mg/ m2,d1;5-FU2400-3000mg/m2,CⅣV(46h), were given, repeated every 14 days; 26 patients in group B treated with FOLFOX6 regimen:L-OHP100 mg/m2,d1;CF400mg/m2,d1; 5-FU400mg/m2,d1;5-FU2400-3000mg/m2,CⅣ(46h), were given, repeated every 14 days.The efficacy,Progression Free Survival(PFS),overall survival (OS) improvement of QOL and toxicity of the two regimens were analyzed. Results:The response rate (RR) of group A and B were 46.40%and 46.20%,Difference was statistically significant(p=0.99). The median PFS was 5.50months in group A and5.50months in group B(P=0.54).The median survival time was 8.00 months in group A and 8.50 months in group B,Difference was statistically significant(p=0.71).The improvement rate of QOL of A and B were 64.30%and 30.80%,Difference was statistically significant(P= 0.04). Major side effect of the two groups had significant deference (P<0.05). Conclusion:Both TF and FOLFOX6 regimens were effective in treating advanced gastric cancer in patients. TF regimen is better than FOLFOX6 regimen on the improvement of QOL and toxicities survivability.更多还原