【作者】 赵军；

【导师】 肖明朝；

【作者基本信息】 重庆医科大学 ， 外科学， 2011， 硕士

【摘要】 目的探讨特拉唑嗪对大鼠灌服左氧氟沙星后前列腺炎组织和血浆中药物浓度的影响。方法建立SD雄性大鼠急性细菌性前列腺炎模型96只,随机分为单服左氧氟沙星组和联合使用特拉唑嗪组,每组48只,分别于给药后0.125、0.25、0.5、1、2、4、8和12 h每个时间点活杀6只大鼠,采集2组动物的血液及前列腺制作组织匀浆,HPLC法测定前列腺组织及血浆的左氧氟沙星浓度,3p97软件计算药动学参数。结果实验组与对照组动物前列腺组织中的左氧氟沙星浓度有显著性差异,而血浆中左氧氟沙星浓度无显著性差异。结论特拉唑嗪可提高左氧氟沙星在大鼠前列腺炎组织中的浓度,而对血浆中的浓度无影响。更多还原

【Abstract】 AIM To investigate the effect of terazosin on the distribution of levofloxacin in the rat’s bacterial prostatitis tissue and plasma.METHOD 96 male SD rats were used to set up the model of acute bacterial prostatitis.,which were equally randomized into two groups: the only levofloxacin orally administered group and the combined terazosin and levofloxacin administered group. Six rats were sacrificed to collect their plasma and prostates to make tissue homogenate at each time point: 0.125 ,0.25 , 0.5 ,1 ,2 ,4 ,8 ,12 h after drug administration. The prostatic and plasma levofloxacin concentrations were detected by HPLC, and pharmacokinetic parameters were calculated by the 3p97 software program.RESULT There isn’t significant difference about the concentration of levofloxacin in plasma between experimental group and control group,but there is significant difference in prostate.CONCLUSION Terazosin can elevate the concentration of levofloxacin in the rat’s prostatitis tissue, but not in the plasma.更多还原