【作者】 肖磊；

【导师】 王净净； 谢静涛；

【作者基本信息】 湖南中医药大学 ， 中西医结合临床， 2011， 硕士

【摘要】 [目的]观察愈痫灵颗粒对癫痫患者认知功能障碍及生活质量的影响。[方法]选择符合诊断和纳入标准的病例61例,按照Doll’s临床随机表法分为治疗组(YXLG组)30例、对照组(VPA组)31例；治疗组给予愈痫灵颗粒,对照组给予丙戊酸钠治疗,疗程3个月,以事件相关电位(P300)、《韦克斯勒成人智力量表中国修订本,WAIS-RC》、癫痫患者生活质量调查问卷-31及癫痫积分评估61例癫痫患者(GTCS)治疗前后P300潜伏期及波幅、智商、生活质量及癫痫发作控制情况,探讨愈痫灵颗粒有改善患者认知功能障碍和生活质量的影响。[结果]①事件相关电位(P300)：癫痫患者P300潜伏期明显延长(P<0.01),提示癫痫患者存在认识功能障碍；愈癫痫灵颗粒能改善癫痫患者的认知功能障碍(P<0.01),丙戊酸纳不能改善癫痫患者认知功能障碍(P>0.05)。②智力测试：愈癫痫灵颗粒有改善癫痫患者智商的作用(P<0.01),丙戊酸纳组治疗后癫痫患者智商降低(P<0.05),提示愈癫痫灵颗粒可提高癫痫患者智商,丙戊酸纳不能改善癫痫患者智商。③癫痫患者生活质量量表：愈痫灵颗粒组及丙戊酸纳组患者生活总积分明显提高(P<0.01),愈癫痫灵颗粒与丙戊酸钠改善癫痫患者生活质量作用优于丙戊酸钠组(P<0.05)。④癫痫积分：治疗和对照组治疗后两组癫痫计分积分均有明显降低(P<0.01),组间比较差异无统计学意义(P>0.05),提示愈癫痫灵颗粒与丙戊酸钠均可有效控制癫痫发作且二者疗效相当；[结论]①与正常成人相比较,癫痫患者P300潜伏期延长,FIQ低于正常,癫痫患者存在认知功能障碍。②愈痫灵颗粒可以改善癫痫患者的认知功能障碍。③愈痫灵颗粒可改善癫痫患者生活质量,且疗效优于丙戊酸钠。更多还原

【Abstract】 [Objective] To observe influence of Yuxianling Granula on cogntive dysfunction and quality of life in patients with epilepsy (GTCS)[Method] Choose 61 available cases according to the diagnosis, and divide them into two groups under the Doll’s clinical random table method. One group is the treatment group (YXLG group), and the other is comparative group (VPA group), YXLG group has 30 cases, VPA group has 31 cases. The treatment group uses Yuxianling Gran-ula, and the comparative group uses VPA. Both Courses of the treatments are there months Observing separately influence of Yuxianling Granula on P300 latency、FIQ and quality of life in patients with epilepsy (GTCS),try to exploring that Yuxianling Granula have the effect of improving Cognitive dysfunction and Qualityof Life. [Results] 1 Compared with the Normal group, the P300 latency and ampfily epilepsy,two group has greet sense in statistics (P<0.01).The comparative in the group:the P300 latency epilepsy of before and the after has greet sense in statistics (P<0.01), the YXLG group clinical effect better than the comparative group.The comparative between the groups:after three months treatment, two group has sense in statistics (P<0.05).The comparative in the group and the comparative between the groups after three months treatment,the P300 ampilfy has no sense in statistics (P>0.05).2 The FIQ of IQ the comparative in the group:the FIQ of IQ of before and the after has greet sense in statistics (P<0.01).3 QOLIE-31 the comparative in the group:the table of QOLIE-31 of YXLG group before and the after has greet sense in statistics (P<0.01). the table of QOLIE-31 of VAP group before and the after has sense in statistics (P<0.05) the compa-rative between the groups:after three months treatment, the table of QOLIE-31 of life of the two group has no sense in statistics (P<0.01), two group clinical effect has no different. The comparative betw-een the groups:after three months treatment, the table of intractable epilepsy of life of the two group has no sense in statistics (P>0.05), two group clinical effect has no different. The comparative between the groups:after three months treatment, the table of intractable epilepsy of life of the two group has sense in statistics (P<0.05), the effect YXLG group on Cognitive dysfunction better than the VPA group.4 The table of intractable epilepsy the comparative in the group:the table of intractable epilepsy of before and the after has greet sense in statistics (P<0.01)[Conclusion] 1 Compared with the Normal group, the P300 latency and ampfily epilepsy of Patients with epilepsy exist cognitive dys-function; 2 YXLG can improve cognitive dysfunction in patients with epilepsy 3 YXLG can improve quality of life in patients with epilepsy,and the effect YXLG group on Cognitive dysfunction better than the VPA group.更多还原