【作者】 肖圣香；

【导师】 纪莉；

【作者基本信息】 吉林大学 ， 临床医学， 2011， 硕士

【摘要】 目的:回顾性分析老年下肢动脉硬化闭塞症与可能的危险因素如性别、年龄、体重、吸烟、血脂、血糖、血压等的相关性,以筛选出老年下肢动脉硬化闭塞症的主要危险因素。同时分析研究老年下肢动脉硬化闭塞症患者的临床表现及其合并高血压病、糖尿病、冠心病、脑梗塞等的临床特点。方法:以2010年1月-2010年12月收入我院干部病房的老年下肢动脉硬化闭塞症患者60例(病例组)及同期住院的老年非下肢动脉硬化闭塞症患者40例(对照组)为研究对象,采用回顾性病例对照研究方法,用SPSS13.0 for Windows统计软件的非条件Logistic回归模型对老年下肢动脉硬化闭塞症可能的危险因素如性别、年龄、体重、吸烟、血脂、血糖、血压等进行回归分析。用SPSS13.0 for Windows统计软件对两组之间高血压病、糖尿病、冠心病、脑梗塞的患病率及超重、吸烟等情况进行χ2检验,比较分析两组之间的差异。同时记录60例老年下肢动脉硬化闭塞症患者的临床表现情况。结果:1.单因素非条件Logistic回归分析结果显示年龄、吸烟、低密度脂蛋白胆固醇、糖尿病与老年下肢动脉硬化闭塞症有不同程度的正相关(P<0.05);而性别、超重、甘油三酯、尿酸、高血压两组之间差异无统计学意义。对年龄、吸烟、低密度脂蛋白胆固醇、糖尿病危险因素进行多因素非条件Logistic逐步回归分析结果显示上述危险因素仍被选入,且具有高度危险性(P<0.01)。2.病例组高血压病、糖尿病、冠心病、脑梗塞的患病率及超重率、吸烟率明显高于对照组,差异有统计学意义。3.60例老年下肢动脉硬化闭塞症患者中有临床症状的17例,其中11例表现为间歇跛行,6例为下肢静息痛。结论:在纳入研究的危险因素中,年龄、吸烟、低密度脂蛋白胆固醇、糖尿病与老年下肢动脉硬化闭塞症密切相关,危险度极高(P<0.01)。老年下肢动脉硬化闭塞症患者大多无明显临床症状,多合并高血压病、糖尿病、冠心病、脑梗塞,而且超重率及吸烟率高。更多还原

【Abstract】 Objective:By retrospective analyzing relativity between elderly lower extremities atherosclerosis disease and its some risk factors,such as sex,age,we- ight,smoking,lipid,glucose,blood pressure, and so on,screen out dominating risk factors correlated with elderly lower extremities atherosclerosis disease.At the same time,analyze and study clinical character of elderly lower extremities ath- erosclerosis disease which contains clinical symptom and the incidence of hyp- ertensive disease,diabetes,coronary heart disease and cerebral infarction.Methods: Sixty elderly patients with lower extremities atherosclerosis di- sease is the case.The control is forty elderly patients who are not lower extremi- ties atherosclerosis disease.These patients are from the cadre ward of the first hospital of Jilin University in 2010. A retrospective case-control study is appli- ed to analyze its some risk factors which are sex,age,weight,smoking,lipid,gluc- ose and blood pressure by SPSS 13.0 for Windows statistical software with no- n-conditional Logistic regression model.χ2 test of SPSS 13.0 for Windows statistical software is applied between the two groups of hypertension,diabetes, coronary heart disease,cerebral infarction and the prevalence of overweight,s- moking,etc to compara the differences.Also clinical symptom of sixty elderly patients with lower extremities atherosclerosis disease is recorded.Results: 1.Single factor non-conditional Logistic regression analysis shows different positive correlation between age,smoking,low-density lipoprot- ein cholesterol,diabetes and elderly lower extremities atherosclerosis disease. But there is no significant difference in gender,overweight,triglycerides,uric ac- id,blood pressure between the two groups.Multivariate non-conditional Logi- stic regression analysis which is applied among age,somking,low-density lipop- rotein cholesterol,diabetes shows that these risk factors are still elected and hig- hly dangerous(P<0.01).2.The prevalence of the case in hypertension,diabetes,coronary heart disease,cerebral infarction overweight and smoking is significa- ntly higher than the control,s.The difference is statistically significant.3.Seve- nteen cases show clinical symptoms in sixty elderly patients with lower extrem- ities atherosclerosis. Intermittent claudication accounts for 11 cases.The remain is rest pain.Conclusions: Age,smoking,low-density lipoprotein cholesterol,diabetes are closely related to elderly lower extremities atherosclerosis disease and are highly risk(P<0.01). Elderly patients with lower extremities atherosclerosis are mostly subclinical and accompany hypertension,diabetes,coronary heart disease, cerebral infarction.And prevalence of overweight and smoking is higher than the contorl,s.更多还原