【作者】 覃艽；

【导师】 刘小凡；

【作者基本信息】 成都中医药大学 ， 中医儿科学， 2010， 硕士

【摘要】 目的：本课题旨在通过观察哮宁口服液与西医常规治疗应用于小儿哮喘发作期的临床疗效,客观评价哮宁口服液的有效性及安全性。方法：本文观察哮宁口服液与西医常规治疗应用于小儿哮喘发作期的临床疗效。研究以60例符合小儿哮喘(寒哮)诊断,年龄在5岁以上患儿为对象,按1：1随机分为治疗组、对照组各30例,治疗组予哮宁口服液口服,对照组予西医常规治疗,系统观察并记录治疗前后主症、次症积分、哮喘症状积分等的变化并进行统计学处理分析。结果：1)临床疗效：治疗组显效率为73.3%,总有效率为96.6%,对照组显效率为90%,总有效率为100%,治疗组与对照组比较,显效率有显著差异(P＜0.05),总有效率无显著差异(P>0.05)。2)哮喘主要症状体征：两组患儿主要症状、体征较治疗前均有明显改善(P<0.05或P<0.01)。组间比较显示,喘息、肺部哮鸣音、气促无显著差异(P>0.05),咳嗽、咯痰有显著差异(P＜0.05)。3)哮喘发作期(寒哮)次证：两组在改善中医次症及舌脉方面,除在神志和小便清长方面无显著性差异(P＞0.05)外,其余均有显著性差异(P＜0.05),治疗组与对照组在治疗后次证总分比较有显著差异(P＜0.05)。4)哮喘证侯积分：治疗后两组哮喘症状评分较治疗前均有明显降低(P＜0.05)。两组治疗后的哮喘症状评分比较,无显著性差异(P>0.05)结论：哮宁口服液应用于小儿哮喘发作期(寒哮),其显效率不及西药组,总有效率与西药组相当,在缓解中医证侯方面疗效明显优于西药组,且在治疗过程中均未出现不良反应,说明哮宁口服液具有良好的安全性。同时哮宁口服液在达到疗效的同时既为患儿家属减轻了熬药的负担,又避免了西药可能带来的副作用,表明哮宁口服液具有良好的临床实用性,值得进一步推广更多还原

【Abstract】 Objective:This study tries to observe clinical effect of Xiaoning Oral Liquid and conventional therapy of western medicine on treatment of cold asthma in children at period of onset, evaluate the efficiency and safety of Xiaoning Oral Liquid objectively.Methods:This article observes the clinical effect of Xiaoning Oral Liquid on treatment of cold asthma in children at period of onset. Take 60 cases of cold asthma in children whose age is above 5 years as research object, divide into two groups, Treatment Group and Control Group, each group 30 cases. The Treatment Group take Xiaoning Oral Liquid, and Control Group apply conventional therapy of Western Medicine. Observe systematically and record the score changes of main symptoms and secondary symptoms, asthma symptom, then analyze with statistics methods.Results:1) Clinical Effect:the treatment Group with 73.3% Excellence Rate and 96.6% total effective rate, the Control Group with 90% Excellence Rate and 96.6% total effective rate, there is obvious difference in Excellence Rate (P<0.05), but no obvious difference in total effective rate (P>0.05).2) Main symptoms and signs of asthma:obvious improved after treatment for both groups (P<0.05 or P<0.01). There is no obvious difference between groups in the symptoms of dyspnea, wheezing and shortness of breath (P>0.05), but obvious difference in the symptoms of cough and coughing up phlegm (P<0.05).3) Secondary symptoms of cold asthma:there is obvious difference between two groups in the improvement of secondary symptoms and the condition of tongue and pulse (P<0.05), except the mind and urine (P>0.05). The score of Treatment Group and Control Group after treatment has obvious difference (P<0.05).4) Score of asthma symptoms and signs:obvious decreased after treatment for both groups (P<0.05), there is no obvious difference between the two groups (P>0.05).Conclusions:Xiaoning Oral Liquid has lower excellence rate, but similar total effective rate with Western Medicine Group, it is even better than Western Medicine Group in relieving the TCM symptoms, there is no adverse effect in the treating processes, so it is quite safe. It not only allows patient’s family far away from trouble of stewing medicinal herbs, but also avoids the side effect of Western Medicine. Xiaoning Oral Liquid obtains satisfactory clinical convenience, it is quite valuable for further spread.更多还原