【作者】 张国强；

【导师】 曹志群；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2010， 硕士

【摘要】 目的：观察清降合方治疗反流性食管炎(reflux esophagitis, RE),中医辨证为肝胃郁火,浊气上逆型的临床疗效,并从理论和临床研究两个方面探讨清降合方治疗肝胃郁火,浊气上逆型RE的机制。方法：临床选择符合纳入标准的RE患者57例,随机分为两组,治疗组(29例)给予清降合方,对照组(28例)给予胃力康颗粒,两组均以4周为一疗程。观察两组的临床疗效,并对治愈患者随访6个月,观察远期疗效。结果：临床研究显示,治疗组在中医证候疗效、胃镜疗效等方面均优于对照组(P<0.05)。治疗组能明显改善烧心、泛酸、胸痛、口苦口粘、纳差等症状,其疗效优于对照组(P<0.05)。两组治疗期间均未发生不良反应。结论：清降合方是治疗肝胃郁火,浊气上逆型RE的有效方剂,其机理可能与抑酸、增强粘膜屏障功能、改善微循环、促进粘膜修复功能等有关。更多还原

【Abstract】 Objective:To observe the effect of Qingjianghefang(QJHF) on Reflux Esop-hagitis (RE) and explore the mechanism of it. Methods:57 patients with RE were divided into two groups at random:the treatment group and the control group. The treatment group was given Qingjianghefang, and the control group was given Weilikang particles.4 weeks were set as a course of treatment.The clinical effects of each group were observed during the course and the follow-up survey of 6 months. Results:The therapeutic effect of the treatment group is better than the control group in syndrome of TCM and gastroscopic observation(P<0.05). Qingjianghefang can improve more significantly the symptoms such as heartburn, belching, retrosternalpain, bitter taste and anorexia (P<0.05). During treatment/the two groups are no adverse reactions.Conclusions:Qingjianghefang appears to have the significant effect in the treatment of RE. The mechanism of this therapy may be relation to relieving hyperacidity enhance the mucosal barrier function、improving blood microcirculation and promoting the mucosal repair更多还原