【作者】 宫海彦；

【导师】 赵泉霖；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2010， 硕士

【摘要】 目的：观察固本祛毒方对早期糖尿病肾病的临床疗效,并探讨TNF-α、ET在早期糖尿病肾病病程中的诊疗意义。方法：给予早期糖尿病肾病患者基础治疗1个月后,将符合标准的60例随机分为两组,对照组继续进行糖尿病教育、降血糖、控制血压等基础治疗,治疗组在对照组治疗基础上加用固本祛毒方,疗程为1个月。比较两组治疗前后临床症状、24 h尿蛋白、TNF-α、ET等变化。结果：治疗组在改善临床症状、降低蛋白尿、炎症分子、改善肾功能等方面均明显优于对照组(P<0.01或P<0.05)。并且在治疗过程中未发生不良反应。结论：固本祛毒方能改善早期糖尿病肾病患者的临床症状,减少炎症分子的表达及尿蛋白的排泄,延缓肾功能损害的进程。更多还原

【Abstract】 Objective:To observe the clinical efficacy of reinvigoration and removing toxicity(RRT) in treatment of early-stage diabetic nephropathy, and to discuss the clinical significance of TNF-αand ET in the course of early-stage diabetic nephropathy.Methods: After one month of the basal treatment for patients with early-stage DN, the 60 cases of patients who measured up the test standard were divided into two groups randomly. The patients in control group were treated continuously with basal treatment including diabetic education, lowering glycemia and blood pressure et,al.While the treatment group were added tranditional Chinese medicine of reinvigoration and removing toxicity on the basis of basal treatment.The period of treatment is one month.The results of clinical symptoms, urinary albumin excretion rate(UAER), TNF-αand ET of before and after treatment were compared.Results:Treatment group was superior to the control group in improving the clinical symptoms, lowering albuminuria, inflammation marker, improving renal function abviously.There was no adverse reactions in the course of treatment. Conclusions:The method of RRT can improve the clinical symptoms of early-stage diabetic nephropathy,low the expression of inflammation marker、the elimination of albuminuria,and postpone the process of renal function damaging of early-stage diabetic nephropathy.更多还原