【作者】 姜晨光；

【导师】 李从举；

【作者基本信息】 北京服装学院 ， 材料学， 2010， 硕士

【摘要】 本论文首先用常规的静电纺丝法制备了聚乳酸( PLLA )、聚乳酸/胶原(PLLA/Collagen)、聚乳酸/羟基磷灰石(PLLA/HA)和聚乳酸/胶原/羟基磷灰石(PLLA/Collagen/HA)生物复合纤维。采用SEM、FT-IR、单轴拉力测试、DSC、XRD和水接触角等测试手段对纤维的形貌结构、结晶性能、热力学性能和浸润性进行了分析表征。结果表明,复合纤维膜具有良好的支架结构,纤维形貌较好,平均直径在400～700nm之间。胶原和HA的掺杂可以在一定程度上调节聚乳酸纤维的力学性能,但由于二者的掺杂量较少,热稳定性和亲水性变化不大。特殊形貌微/纳米纤维是近几年来逐渐受到重视的纤维材料,本论文利用实验室自制的双电极静电纺丝装置探索了一系列基于热塑性聚酯弹性体(TPEE)和基于聚乳酸的双组分纤维材料。分别将这两种高聚物与PVP、PCL、PEG等具有一定生物活性或亲水性的物质进行组合,制备了具有特殊形貌的纤维材料。通过SEM表征发现,不同高聚物组分的结合以及溶剂体系的选择对纤维形貌有较大影响,经分析可能是由于高聚物收缩性的差异及不同溶剂体系之间的差异造成的。同时,也说明双电极静电纺丝装置可适用于多种不同溶剂的高聚物组分之间的结合,为特殊形貌微/纳米纤维材料的制备和应用提供了新的途径,具有很大的应用前景。更多还原

【Abstract】 In this paper, PLLA, PLLA/Collagen, PLLA/HA and PLLA/Collagen/HA bio-composite nanofibers were prepared by traditional electrospinning. The fiber morphology, the crystallization behavior, the thermal and mechanical properties and the hydrophilicity were characterized by SEM, FT-IR, uniaxial tensile test, DSC, XRD and water contact angle measurement. The results showed that the composite fiber mats had relatively ideal fiber morphology and scaffold. The average diameters were about 400~700nm. With the addition of collagen and HA, the amount of which was small, the mechanical property of the composite fibers have been enhanced, while the thermal property and the hydrophilicity has not been changed obviously.Recently, the micro/nanoscale fibers with special morphologies have attracted increasing attention. In this paper, a series of bicomponent fiber materials separately based on TPEE and PLLA have been prepared by a novel double-electrode electrospinning. Other components coupled with TPEE or PLLA include PVP, PCL, PEG and so on, most of which are biomaterials and hydrophilic materials. SEM images showed that the polymer materials and their solvents have great influence with the morphology of the bicomponent fibers, which was probably due to the different shrinkage of the polymers and the nature of the solvents. Double-electrode electrospinning can be used to prepare bicomponent fibers of large numbers of polymers. It provides a new way to produce fibers with special morphologies and has great application prospects.更多还原