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基于正交实验设计的磺胺甲恶唑在渔业水体中的消解动态规律

Sulfamethoxazole in Aquaculture Water by Orthogonal Experimental Design: Degradation Dynamics

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【作者】 方龙香宋超范立民孟顺龙裘丽萍陈家长

【Author】 Fang Longxiang;Song Chao;Fan Limin;Meng Shunlong;Qiu Liping;Chen Jiazhang;Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences;Laboratory of Quality &Safety Risk Assessment for Aquatic Products on Environmental Factors (Wuxi), Ministry of Agriculture and Rural Affairs;Key Laboratory of Control of Quality and Safety for Aquatic Products, Ministry of Agriculture and Rural Affairs;

【通讯作者】 宋超;陈家长;

【机构】 中国水产科学研究院淡水渔业研究中心农业农村部水产品质量安全环境因子风险评估实验室(无锡)农业农村部水产品质量安全控制重点实验室

【摘要】 为了探究磺胺甲恶唑(sulfamethoxazole, SMZ)在渔业水体中的自然降解规律,本试验选取养殖水环境中常见的因素(温度、pH值、敞蔽条件),通过正交实验探究这3个因素对SMZ在自然养殖水体中消解动态的影响。试验初期各处理SMZ浓度保持一致,实验周期内定期取水样检测水体中SMZ的浓度变化,SMZ消解动态符合一级反应动力学方程,计算各处理中SMZ药物的半衰期和消除率。结果表明:18个处理组SMZ的半衰期及其消除率变化范围分别为4.88~12.89天、28%~77%。方差分析得出:在实验水平范围内,温度、pH值因素对SMZ的消解结果有显著影响,但敞蔽的影响较小。因此,适当提高养殖水体温度、调节水体pH值等条件均有利于促进SMZ的降解。

【Abstract】 To explore the natural degradation rule of sulfamethoxazole(SMZ) in aquaculture water, we selected common factors in aquaculture water environmental(temperature, pH value and open or cover system conditions), and studied the effects of these 3 factors on degradation dynamics of SMZ in natural aquaculture water by the orthogonal experiment. The SMZ concentration of each treatment remained consistent in the initial stage of the experiment; water samples were taken regularly to detect the change of SMZ concentration in water body, which was consistent with the first-order kinetic equation, and the half-life and the elimination rate of SMZ in each treatment were calculated. The results showed that: the variation range of half-life of SMZ and its elimination rate in 18 treatment groups was 4.88-12.89 days, 28%-77%, respectively. Anova analysis showed that: within the range of the experimental level, temperature and pH value had a significant influence on elimination of SMZ, but the influence of the open or cover condition was small. Therefore, properly improving the conditions of temperature and pH value of aquaculture water is conducive to promote the degradation of SMZ.

【基金】 国家重点研发计划课题“典型养殖用药的迁移规律及防控技术”(2017YFC1600704);中央级科研院所基本科研业务费“水产养殖抗生素减量与替代的精准化技术研究”(2019JBFZ04);国家自然科学基金青年基金项目“不同剂量抗生素磺胺甲噁唑对罗非鱼肠道微生态-宿主代谢轴调节的差异性研究”(31802271)
  • 【文献出处】 中国农学通报 ,Chinese Agricultural Science Bulletin , 编辑部邮箱 ,2019年27期
  • 【分类号】X714
  • 【被引频次】7
  • 【下载频次】218
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