【摘要】 针对生物药剂学分类系统(biopharmaceutics classification system,BCS)是依据药物溶解性和渗透性对药物进行分类并提供药物生物利用度-吸收关联分析的一种科学框架或方法,课题组基于中药多成分多靶点的特色及BCS的理念、方法和技术,提出中药生物药剂学分类系统(biopharmaceutics classification system of Chinese materia medica,CMMBCS)并以经典方为基础进行了研究和数据积累。结合前期研究成果,在CMMBCS概念和框架下提出进一步的发展思路:在研究过程中,省略多成分环境的复杂相互作用的中间环节影响,直接关注复方成分发挥主要临床疗效的成分吸收研究,或从代谢、药效通路和吸收原理等方面反推吸收成分和数据,从单成分和复方2个方面进行研究,全面评价中药复方及组方中药的吸收属性;在研究路径中,充分考虑中药发挥药效的不同途径,并重点以吸收入血途径开展CMMBCS分类归属与树立规律;在具体方法上,拓展应用网络药理学及分子对接技术筛选中药复方指标成分和通过PBPK模型研究体内吸收,反向推理计算CMMBCS吸收参数,并通过药效或吸收途径研究修正中药复方CMMBCS分类归属。通过对CMMBCS基础理论确立、以药效导向的研究思路补充及现代成熟中药方法学的拓展应用,在研究基础上对CMMBCS的理论框架和研究方法学进行了系统完善。更多还原

【Abstract】 The biopharmaceutics classification system( BCS) is a scientific framework or method for classifying drugs based on drug solubility and permeability,which can be used to provide drug bioavailability-absorption correlation analysis. Based on the characteristics of multi-component and multi-target of traditional Chinese medicine( TCM) as well as the concept,method and technology of BCS,the research group proposed biopharmaceutics classification system of Chinese materia medica( CMMBCS) and carried out research and data accumulation of classical prescriptions. Based on the previous research results,further development ideas under the CMMBCS concept and framework were further proposed in this study. In the course of research,the influence of the intermediate links of the complex interactions of the multi-component environment was omitted,and the component absorption studies on the main clinical effects of prescription ingredients were directly concerned,or the components and data were reversely extracted from the aspects of metabolism,pharmacodynamic pathways and absorption principles. Studies were conducted from two aspects( single component and compound prescription) to comprehensively evaluate the absorption properties of TCM compound. In the research path,the different ways in which Chinese medicine could exert its efficacy were fully considered,and CMMBCS classification and establishment rules were clarified mainly by focusing on the absorption pathway into the blood. Specifically,the network pharmacology and molecular docking technology were used to screen the compound index components of TCM; the absorption rules were studied by the physiologically based pharmacokinetic models and the absorption parameters of CMMBCS were calculated by reverse reasoning. Then the CMMBCS classification of TCM prescription was corrected by studying the efficacy or absorption pathway. In this paper,the theoretical framework and research methodology of CMMBCS were systematically improved based on the establishment of CMMBCS basic theory,the supplementary of drug-oriented research ideas and the application of modern mature Chinese medicine methodology.更多还原