【摘要】 目的评价四川省5.12地震灾区甲肝疫苗(HepA疫苗)群体性接种的效果。方法采用随机抽样的方法,检测四川省5个开展了灾后甲肝疫苗(HepA疫苗)群体性接种的灾区县和5个对照县1～12岁健康儿童的甲肝(HAV)IgG抗体,并比较灾区县和对照县在接种前后甲肝报告发病水平。结果灾区县1～12岁健康儿童血清HAV-IgG抗体阳性率为72.40%,对照县为39.87%(两者差异有统计学意义);灾区县在开展灾区HepA疫苗群体性接种前的3年平均发病率高于对照县,在开展接种后的2年平均发病率低于对照县,差异均有统计学意义。结论四川省5.12地震灾区HepA疫苗群体性接种产生了良好的免疫效果,有效的控制了地震后灾区甲肝的发病水平。更多还原

【Abstract】 OBJECTIVE To evaluate the effect of mass immunization activity of hepatitis A vaccine at 5.12 earthquake area in Sichuan province.METHODS Carried out random sampling to investigate the HAV IgG of healthy children aged 1-12 years from 5 earthquake counties with mass immunization of HepA vaccine and 5 contrast counties;compared HepA incidence of the disaster counties and contrast counties before and after the vaccination in statistics.RESULTS The positive rate of HAV-IgG in the children from disaster counties was 72.40%,which in the contrast county was 39.87%,and differences were significant.During the 3 years before the massive vaccination,the average incidence of HepA in disaster counties was higher than that of contrast counties;during the 2 years after the massive vaccination,and the average incidence of HepA in disaster counties was lower than that of contrast counties,and the differences were significant.CONCLUSION Mass immunization activity of hepatitis A vaccine at the 5.12 earthquake area achieves the great impact to control the incidence of HepA effectively.更多还原