【摘要】 我国癌症发病群体不断年轻化,发病率不断增加。最近科学研究表明,细胞代谢相关调控基因已成为新的癌症诊断标记和治疗靶点。一碳代谢对于细胞代谢必不可少,一碳代谢需要叶酸、丝氨酸和蛋氨酸等细胞必需的生物代谢物质参与,同时也产生嘌呤、腺苷和胸苷酸等生物代谢物质。一碳代谢包括三类关键反应:叶酸循环、蛋氨酸循环、反硫化途径。在叶酸循环中,叶酸及叶酸循环中间产物可以通过产生嘌呤和胸苷酸调控癌症细胞的生长和增殖。在蛋氨酸循环中产生的多胺和甲基等中间产物也能调控癌症细胞的生长和增值。反硫化途径是谷胱甘肽合成的重要途径,谷胱甘肽能够生成与肿瘤细胞密切相关的活性氧。该研究将简要综述一碳代谢在癌症发生中的作用,概况了近年来一碳代谢通路重要因子及中间产物作为靶点对癌症治疗的意义。更多还原

【Abstract】 In China, the incidence of cancer is getting higher as well the patients are younger than before.Recently, scientific research shows that the regulation genes relation of cellular metabolism has being as a new target for cancer diagnosis and treatment. One-carbon metabolism is essential for cell metabolism, during this process,not only require folate, serine and methionine, but also can produce the other biological macromolecules, such as purine, adenosine and thymide. Three kinds of key reactions are included in one-carbon metabolism: folate cycle,methionine cycle and trans-sulfuration pathway. In the folate cycle, folate and its intermediates regulate the growth and proliferation of cancer cells by providing purine and thymidine. Moreover, polyamines and DNA methyl groups also regulate the growth and proliferation of cancer cells in the methionine cycle. The tran-sulfurization pathway is an important pathway for the synthesis of glutathione, which can generate reactive oxygen species(ROS) closely related to tumor cells. In this paper, the role of one-carbon metabolism in cancer development is briefly reviewed.And the significance of some important factors and intermediates in one-carbon metabolism is summarized, which might be as the targets for cancer treatment.更多还原