【摘要】 长链非编码RNA(long non-coding RNAs,lncRNAs)是一类由长度大于200个核苷酸组成的长链非编码序列。lncRNAs具有较长的序列,使得lncRNAs具有复杂的二级及三级结构,这也是lncRNAs结合DNA、RNA和蛋白质及其行使复杂功能的结构基础。MicroRNA(miRNAs)是长度在19到25个核苷酸之间的非编码单链RNA分子,是目前研究最多的小分子非编码RNA。而lncRNAs通过结合或者螯合miRNA来调节miRNA丰度,发挥lncRNA的"海绵"作用,从而调控一系列的病理生理过程。lncRNAs及miRNA在呼吸系统疾病的发生、发展、治疗和预后起重要作用。本文就lncRNAs及其"海绵"作用对呼吸系统疾病的影响及可能的机制进行综述。更多还原

【Abstract】 Long non-coding RNAs(lncRNAs) are a class of long non-coding sequences composed of more than 200 nucleotides. Because of its longer sequences,lncRNAs have a complex secondary and tertiary structure,which is the structural basis for lncRNAs to bind DNA,RNA,and proteins and perform complex functions. MicroRNAs(miRNAs) are a class of small non-coding RNAs(19-25 nucleotides),which is the most studied type of small non-coding RNAs. lncRNA can act as a "sponge"by combining with miRNAs to regulate a series of pathophysiological processes. lncRNAs and miRNAs play an important role in the occurrence,development,treatment and prognosis of respiratory diseases.This article reviews the effects and mechanisms of lncRNA acting as sponges on respiratory diseases.更多还原