【摘要】 建立了高效液相色谱法测定化妆品中辛酰羟肟酸含量的分析方法。样品采用甲醇超声提取,经XBridge C₁₈色谱柱分离,高效液相色谱/二极管阵列检测器检测,以保留时间和紫外吸收光谱定性,外标法定量。结果表明,辛酰羟肟酸浓度在1～200 mg/L范围内线性关系良好,相关系数为0.999 9。在20、100、150 mg/L 3个浓度水平进行样品加标实验,回收率为97.2%～104.6%,相对标准偏差在0.48%～1.90%（n=6）,方法检出限为0.001%。本方法操作简便、快速、准确,适用于各类化妆品中辛酰羟肟酸含量的测定。更多还原

【Abstract】 A method for the determination of caprylohydroxamic acid in cosmetics by high performance liquid chromatography was established.Cosmetic samples were extracted by methanol ultrasound,separated by XBridge C₁₈ column,detected by diode array detector,and quantified by external standard method.Under the optimized experimental conditions,the linear relationship of caprylohydroxamic acid concentration was good in the range of 1～200 mg/L,and the correlation coefficient was 0.999 9.The recovery was 97.2%～104.6%,the relative standard deviation was 0.48%～1.90%（n=6）,and the detection limit was 0.001% when the standard addition experiments were carried out at the concentration levels of 20,100 and 150 mg/L.The method is simple,rapid and accurate.It is suitable for the determination of caprylohydroxamic acid in various cosmetics.更多还原