【摘要】 萜类化合物具有可观的商业价值,但生产过程复杂,产量低,利用微生物异源合成萜类化合物已成为热点。谷氨酸棒状杆菌内含合成萜类色素的途径,具有异源合成萜类化合物的天然优势和研究前景。首次对谷氨酸棒状杆菌合成萜类化合物进行了综述,从萜类合成途径、关键酶和全局调控机制三个方面进行了途经介绍。概述了谷氨酸棒状杆菌中单萜、倍半萜、四萜类化合物的异源合成,并对利用谷氨酸棒状杆菌高效合成萜类化合物所需解决的问题进行讨论,为谷氨酸棒状杆菌高效合成萜类化合物提供建议。更多还原

【Abstract】 Terpenoids have considerable commercial value,but the production process is complex and the yield is low. It has become a hot spot to synthesize terpenoids from microorganism. Corynebacterium glutamicum contains a pathway to produce carotenoid, which is a natural advantage for the synthesis of terpenoids heterologously. The synthesis of terpenoids from C. glutamicum is summarized,including the terpenoids synthesis pathway in C. glutamicum,key enzymes and global regulatory mechanisms in this pathway. And the advances in this pathway in synthesis of monoterpenes,sesquiterpenes,and tetraterpenes are summarized. The problems and advice efficient synthesis of terpenoids by C. glutamicum is discussed.更多还原