【摘要】 近几年来,基因编辑技术快速发展,为在特定位置精确操控基因组提供了一个有效而精确的工具。CRISPR/Cas9系统是一种新型的基因编辑工具,可实现对人类基因组的高精度修饰,是疾病建模和治疗的可行选择。随着CRISPR/Cas9系统技术的广泛应用,在糖尿病领域有不少相关研究出现。该文从干细胞分化为β细胞、基因编辑重编程为β细胞以及修饰基因三个方面总结了CRISPR/Cas9技术在糖尿病治疗中的应用。更多还原

【Abstract】 In recent years, the rapid development of gene editing technology has provided an effective and accurate tool for the manipulation of genomes at specific locations. CRISPR/Cas9 system is a new gene editing tool, which can achieve high-precision modification on human genome and is a feasible strategy for disease modeling and treatment. CRISPR/Cas9 system has been widely applied in many research fields, including diabetes cell therapy. In this review, we summarized recent advances of CRISPR/Cas9 in the treatment of diabetes mellitus, especially in the differentiation of stem cells into β cells, direct reprogramming into beta cells, and genes modification.更多还原