【摘要】 类器官弥补了传统研究中细胞简单模型与动物复杂模型的不足,为生命体关键功能研究提供了重要实验基础,已成为当前研究热点,并在疾病机理研究、药物筛选、再生医学、生物材料评价等方面具有重大理论意义和应用前景.本文对近10年类器官研究进行了综述,阐述出类器官研究的发展历程和研究现状,重点综述了类器官的主要研究领域,并解析类器官研究中存在的关键科学问题,为类器官在生物医药、再生医学和疾病精准治疗领域的研究和应用提供新思路.更多还原

【Abstract】 Organoid can make up for the deficiency of cell models and animal models commonly used in traditional research. And it also provides an important experimental basis for the study of key functional studies of living organisms. At the present stage, organoid model has become a hot research field and is of great significance in disease mechanism research, drug screening, regenerative medicine, and biomedical material evaluation. In this paper, the research of organoids in the past 10 years is reviewed. It summarizes the development history and research status of organoid research, and also focuses on the main research fields of organoids. In addition, this paper mainly analyzes the key scientific issues in the study of organoids and propose ideas for organoid in biomedicine, regenerative medicine and precise treatment of diseases.更多还原