【摘要】 以四氧化三铁为代表的医用磁性纳米材料具有独特的磁学性能、表面易功能化、良好的生物学相容性等特点,在纳米医学相关领域展现出巨大的应用前景,特别是近年来它作为可介导外场的智能材料,在材料设计和生物医学应用方面均取得了突破性的进展.鉴于此,本文围绕磁性氧化铁纳米材料的生物医学应用,着重介绍近年来其在磁共振影像探针、磁热和磁力效应的生物医学应用、诊疗一体化以及纳米酶催化等领域的研究进展,并对磁性纳米材料在生物医学领域未来的发展方向进行了展望.更多还原

【Abstract】 Ferroferric oxide,a respresentative of biomedical magnetic nanomaterials, have shown great potential in nanomedicine because of their unique size-dependent properties, easy surface functionalization and good biocompatibility. Recently, great progress in this field has been achieved in materials design and biomedical applications, especially, the iron oxide nanomaterials can be used as intelligent materials to mediate the external field. To highlight these achievements, here we discuss the biomedical applications of magnetic nanoparticles in magnetic resonance imaging contrast agents, magnetic hyperthermia and magnetic force controlled biological effect, magnetotheranostics and nanozymes. With the quick development in nanomedicine, magnetic nanoparticles-based diagnostics and therapeutics are believed to play vital roles in tackling major disease in the future.更多还原