【摘要】 桥粒不但参与上皮和心肌细胞的连接,增强细胞承受机械应力时的黏附作用,还能调控细胞行为和组织形态发生改变时的信号传导通路过程.桥粒相关蛋白Pinin(PNN)自发现以来,其位置和功能就备受争议.现有结果表明,PNN包含与细胞膜上桥粒共定位的桥粒型PNN和位于细胞核中的核型PNN两种,前者参与上皮细胞的黏附,后者与m RNA的选择性剪接功能有关.新近研究发现,PNN与肿瘤发生密切相关,然而其作用及其分子机制却不相同.本文对PNN的结构、功能及其与肿瘤发生的关系作一综述.更多还原

【Abstract】 Desmosome not only participates in the connections of epithelial cell and cardiomyocyte to enhance the cell adhesion when subjected to mechanical stress, it also regulates signal pathways of cell behavior. Since the discovery of Pinin(PNN), a desmosome-associated protein, its position and function are controversial. Current results indicate that PNN has two types: a desmosome-like PNN co-localized with desmosomes on the cell membrane, and a karyotype PNN located in the nucleus. The former participates in epithelial cell adhesion, the latter is related to the alternative splicing function of genes. Recent studies have found that PNN is closely related to tumorigenesis via different molecular mechanism. This article reviews the biological function of PNN and its relationship with tumorigenesis.更多还原