【摘要】 目的:通过测定创伤后应激障碍(PTSD)患者血清丙二醛(MDA)及血浆超氧化物歧化酶(SOD)水平,探讨PTSD患者是否存在显著的脂质过氧化。方法:地震灾后1年,对596例参加抗震救灾的志愿者进行PTSD问卷调查,确诊为PTSD者24例,对其中18例(PTSD组)和32名未参加抗震救灾的健康招募者(对照组)进行血清MDA浓度及血浆总SOD活性检测。结果:两组血清MDA浓度及血浆SOD活性均为非正态分布资料;运用等级资料检验,两组血清MDA浓度及血浆SOD活性水平差异均存在显著的统计学意义(P=0.008,0.007)。结论:PTSD患者存在显著的脂质过氧化。更多还原

【Abstract】 Objective:To determine whether there is significantly lipid peroxidation in post-traumatic stress disorder(PDST)by assessing serum malondialdehyole(MDA)level and plasma activity of total superoxide dismutase(SOD)in a group of PTSD patients.Method:One year after earthquake relief,596 volunteers of earthquake relief were screened by questionnaires for PTSD.Twenty-four PTSD patients were diagnosed by structured interview.Blood samples were drawn from 18 PTSD patients and 32 control peoples who did not participate in earthquake relief,and serum MDA level and plasma activity of total SOD were detected.Results:The data of serum MDA level and plasma activity of total SOD in the two groups were abnormal distribution.There were significant differnece on serum MDA level and plasma activity of total SOD between PTSD group and control group.Conclusion:Our results suggest that marked lipid peroxidation seems to be related to PTSD.更多还原