【摘要】 传统癌症治疗方法(如化疗、放疗和手术切除等)存在对正常组织的严重毒副作用和治疗效果差等缺点,从而阻碍了其在临床治疗中的进一步应用.随着纳米技术和纳米医学的快速发展,能量转换生物材料介导的治疗方式,由于其具有非侵入性、较强的组织穿透能力和对治疗剂量的精准调控等优势而受到广泛关注和研究.本文总结了近年来本研究团队在"能量转换生物材料"(包括光-热转换、光-化学能转换、超声-化学能、超声-热能转换、磁-热能转换和化学能-化学能转换)的设计、制备及其在癌症治疗中的应用,并讨论了"能量转换纳米医学和生物材料"在未来临床转化中的应用前景和面临的挑战.更多还原

【Abstract】 Severe side effects on the surrounding normal tissues and low therapeutic efficiency hinder the further biomedical applications of conventional cancer therapies(chemotherapy, radiotherapy, surgery, etc.). With the rapid development of nanotechnology and nanomedicine, energy-conversion biomaterial-mediated therapies have received extensive attention due to their non-invasive feature, high tissue-penetration depth and precise regulation of therapeutic doses. In this review, we summarize our recent research progress on the design of energy-conversion biomaterials(photo-to-thermal energy conversion, photo-to-chemical energy conversion conversion, ultrasound-to-chemical energy,ultrasound-to-thermal energy conversion, magnetic field-to-thermal energy conversion, and chemical energy-tochemical energy conversion) and their application in cancer treatment, and discuss the prospects and challenges of energy-conversion nanomedicine in the future clinical translation.更多还原