【摘要】 目的研究经历同源创伤后患创伤后应激障碍(PTSD)患者的脑静息状态默认网络,探索PTSD的发病机制。方法 17例地震PTSD患者和20例正常对照者接受静息态功能磁共振扫描。分别以左、右侧后扣带回为种子点行全脑静息态功能连接分析并进行组间比较。结果 PTSD组与对照组相比,在静息状态下脑功能连接减低的区域包括左额上回、右梭状回,而功能连接增强的区域包括右楔前叶及右侧颞上回和右侧颞中回。结论 PTSD患者在静息状态下存在默认网络功能连接异常,默认网络异常可能是PTSD的神经病理机制之一。更多还原

【Abstract】 Objective To explore the pathogenesis of posttraumatic stress disorder(PTSD) by studying default mode network during the resting state in patients with PTSD after homologous traumatic experience.Methods Seventeen PTSD patients and 20 matched normal controls received the examnation of resting-state fMRI scanning.Left and right posterior cingulate cortex was regarded as seed region respectively,and the functional connectivity about whole brain was assessed by using resting-state functional connectivity analysis.Results Compared with control group,the patients with PTSD showed that the brain area with decreased functional connectivity included left superior frontal gyrus and right fusiform gyrus,while the brain area with increased functional connectivity included right precuneus,right superior temporal gyrus and right middle temporal gyrus.Conclusion The brain default mode network of PTSD patients is abnormal in resting state.These abnormalities might be the neuropathological mechanisms of PTSD.更多还原