【摘要】 为了初步探索木薯淀粉微球用作局部止血材料的止血性能,本研究以酸改性木薯淀粉为原料,三偏磷酸钠为交联剂,采用水包水乳液-交联法制备木薯淀粉微球。通过体外和体内止血试验评价木薯淀粉微球的止血性能。研究结果表明,木薯淀粉微球组的全血凝固时间、血浆复钙时间及家兔脾脏划破止血时间均显著低于空白对照组(P<0.05),与云南白药组相比无显著差异(P>0.05)。初步证明木薯淀粉微球的体外及体内止血性能良好,具有用作局部止血材料的良好潜力。更多还原

【Abstract】 To preliminarily investigate the hemostatic properties of cassava starch microspheres as topical hemostatic material,using acid modified tapioca starch as raw material and sodium trimetaphosphate as cross-linking agent,cassava starch microspheres were prepared by water-in-water emulsion-crosslinking method. The hemostatic properties of cassava starch microspheres were evaluated by in vitro and in vivo hemostatic tests. The whole blood coagulation time,recalcification time and the hemostatic time of experimental splenic bleeding model in rabbit in the cassava starch microsphere group were significantly lower than that in the blank control group( P < 0.05),and there were no significant differences when compared with the Yunnan Baiyao group( P > 0.05). The results preliminarily showed that cassava starch microspheres had good hemostatic performance in vitro and in vivo,and had good potential as a topical hemostatic material.更多还原