【作者】 米兰；

【导师】 欧阳恒；

【作者基本信息】 湖南中医药大学 ， 中医外科学， 2006， 博士

【摘要】 目的:观察竹黄颗粒剂Ⅱ号对趋化因子IL-8和RANTES的影响,探讨其作用机理。方法:临床观察治疗共纳入60例,男33例,女27例,随机分为竹黄颗粒剂Ⅱ号治疗组(治疗组)和银屑灵冲剂治疗组(对照组)。采用ELISA法检测血清和皮损中IL-8及RANTES的含量。另纳入10名健康人为正常组。治疗前后分别进行银屑病面积与严重程度指数(PAIS)和皮肤病生活质量(DQOLS)的评估。结果:1.竹黄颗粒剂Ⅱ治疗银屑病的有效率为93.3%,优于银屑灵的73.3%(P＜0.05)。2.竹黄颗粒剂Ⅱ号能较好改善银屑病人生活质量(P＜0.05)。3.竹黄颗粒剂Ⅱ号能较好缩小银屑病患者皮损面积,改善红斑、丘疹、鳞屑、瘙瘁症状(P＜0.05),优于银屑灵冲剂治疗组(P＜0.05)。4.竹黄颗粒剂Ⅱ号能减少血清及皮损中IL-8的含量(P＜0.05),优于银屑灵冲剂治疗组(P＜0.05)。血清中IL-8含量与皮损中IL-8含量成正相关。5.竹黄颗粒剂Ⅱ号能减少血清及皮损中RANTES的含量(P＜0.05),优于银屑灵冲剂治疗组(P＜0.05)。血清中RANTES含量与皮损中RANTES含量成正相关。结论:竹黄颗粒剂Ⅱ号治疗用于治疗银屑病有较好的临床疗效。研究表明其能降低血液及皮损中趋化因子IL-8和RANTES含量,减轻局部炎症浸润,抑制角质形成细胞过度增殖,从而达到治疗银屑病的目的。更多还原

【Abstract】 Objective: To investigate the mechanism of Zhu Huang Granule-II in the treatment of psoriasis vulgaris and to observe its effects on Chemokine IL-8 and RANTES.Method: 60 suffers involed were divided into two groups, treated group (n=30) and control group(n=30) at random. The patients in treated group were treated with Zhu Huang Granule-II (ZHG-II), which in control group were treated with Yingxueling chong ji . The level of IL-8 and RANTES were detected by ELISA, both in sera and lesion samples, before and after treatment.10 healthy persons were tested also, acting as normal compare group. Psoriasis area and severity index(PAIS)and dermatosis quality of life statistical forms (DQOLS) were evaluated before and after treatment.Results: 1. The level of IL-8 in sera and leision samples after treatment were lower than that of before treatment (P<0. 05). Treatment group was better than control group (P<0. 05). 2. The level of RANTES in sera and leision samples after treatment were lower than that of before treatment(P<0.05). Treatment group was better than control group(P<0.05). 3. PAIS index reduced(P<0.05). 4. DQOLS index reduced (P<0. 05).Conclusion: It was suggested from the results that ZHG-II Zhu could reduce the level of IL-8 and RANTES both in sera and lesion samples. So that it can improve suffers’ clinical symptoms and living quality.更多还原