【作者】 郝亮；

【导师】 周翠英；

【作者基本信息】 山东中医药大学 ， 中西医结合临床， 2009， 博士

【摘要】 目的:评价补肾强脊汤治疗强直性脊柱炎(AS)肾虚血瘀证的疗效与安全性。方法:采用随机、对照方法,将60例AS肾虚血瘀证患者随机分为中药组和西药组,中药组予以补肾强脊汤治疗,西药组给予柳氮磺胺吡啶(SASP)治疗,连续用药6个月。采用国际ASAS工作组制定的ASAS20、BASDAI50标准及中医证候疗效标准,评价中药治疗AS的疗效。结果:两组患者Bath病情活动指数、Bath功能指数、疼痛、炎症指数等临床症状均有明显的改善,腰椎前屈、腰椎侧弯、ESR、CRP亦有改善;治疗组中医临床症状改善明显。结论:补肾强脊汤治疗AS临床疗效满意,其作用机制可能与抗炎、镇痛、改善血流变、增强免疫、抑制破骨细胞等有关,安全性及依从性好,有广阔的应用前景。更多还原

【Abstract】 Objective: To evaluate the curative effect and security of the invigorating kidney and stronging ridge soup used to treat kidney deficiency and blood stasis of ankylosing spondylitis (AS) .Methods: Applying a randomized, control methods, 60 cases of kidney deficiency and blood stasis in patients with AS were randomly divided into traditional Chinese medicine and western medicine group.The first group were given the invigorating kidney and stronging ridge soup, the western medicine group were given sulfasalazine (SASP) treatment, continuous medication for 6 months. Adopting the ASAS20 and BASDAI50 standards developed by international ASAS Working Group and efficiency of TCM Syndromes criteria to evaluate the efficiency of Chinese medicine treatment of AS.Results: The Bath disease activity index, Bath functional index, pain、inflammation index and clinical symptoms have shown obvious improvement, lumbar flexion, lumbar scoliosis, ESR, CRP were also improved.The treatment group’s clinical symptoms improved significantly.Conclusion: The invigorating kidney and stronging ridge soup used to treat AS has obtained satisfying clinical effects.its function mechanism possibly related to the anti-SARS, the analgesia, the improvement blood stream change, the enhancement immunity, suppressing the osteoclast and so on.its security and the compliance is good, it has the broad application prospect.更多还原