【作者】 丛维娜；

【导师】 刘耕陶； 叶菲； 田金英； 朱海波； 张建军；

【作者基本信息】 中国协和医科大学 ， 药理学， 2008， 博士

【摘要】 随着生活方式和饮食结构的改变,代谢综合征的发病率日益增高。代谢综合征是一种以肥胖、胰岛素抵抗及脂质代谢紊乱等为特征的疾病,其在肝脏的表现为非酒精性脂肪性肝病(non-alcoholic fatty liverdisease,NAFLD)。NAFLD主要包括单纯性脂肪肝、非酒精性脂肪性肝炎(non-alcoholic steatohepaitis,NASH)、以及肝硬化三个阶段,其中NASH是NAFLD发展过程中的关键阶段。对NASH的发病机制和防治措施的研究已经成为NAFLD研究的焦点。代谢综合征发病机制复杂且受多种因素调控,多需要长期的药物治疗,因此从天然产物中寻找疗效肯定、毒副作用小的预防和治疗代谢综合征的药物显得尤其重要。基于对代谢综合征的上述两方面的研究现状了解及关注,本文论文内容主要分为“代谢综合征合并非酒精性脂肪肝炎小鼠模型的建立”和“银杏叶提取物治疗代谢综合征作用及其机制的探讨”两个部分。更多还原

【Abstract】 The prevalence of metabolic syndrome,which is characterized by obesity, insulin resistance and dyslipidaemia,has increased dramatically accompanied with the changes of life style and diet composition.As a hepatic manifestation of metabolic syndrome,non-alcoholic fatty liver disease(NAFLD) also becomes prevalent and includes simple steatosis,non-alcoholic steatohepatitis(NASH) and liver cirrhosis.Non-alcoholic steatohepatitis(NASH),a crucial stage of NAFLD,leads to liver cirrhosis.The pathogenesis and the treatment of NASH are not clear and need further research.As to the treatment of metabolic syndrome, natural products that are safe and have multiple pharmacological effects could be potential therapies,because of the complexity and chronic intervention of metabolic syndrome.Ginkgo biloba leavesare such kind of natural product and has been widely used in clinic both in and outside of China.As a standardized and well-defined product of Ginkgo biloba leaves,EGB761 not only has anti-oxidant and anti-inflammation activity but also could improve serum lipid profiles and hyperglycemia in type 1 diabetes rat model.Focused on above two aspects of metabolic syndrome,two parts of work are presented in this dissertation and named as "Establishment of a metabolic syndrome related non-alcoholic steatohepatitis mouse model" and "studies on the effects of EGB761 on metabolic syndrome and its mechanisms".更多还原