【作者】 于丽红；

【导师】 王新陆；

【作者基本信息】 山东中医药大学 ， 中医内科学， 2008， 博士

【摘要】 目的:探讨急性脑梗塞患病人群入院前血浊证的主要症状、实验室诊断指标及影响因素,为血浊证诊断的进一步规范化及中医药早期有效防治脑梗塞提供科学依据。方法:应用流行病学研究的方法,通过专家咨询、查阅文献,制订调查问卷,通过小样本预调查对问卷信度及效度进行评价并修改完善,问卷定稿后,进行大样本流行病学调查,获得临床资料,进行数据挖掘及医理分析,对急性脑梗塞患病人群入院前血浊证的主要症状、实验室诊断指标及影响因素进行深入探讨。结果:研制了《急性脑梗塞患者入院前血浊证的流行病学研究》调查问卷,经临床大样本调查证明该问卷具有较好的信度和效度;通过频数分析、均数分析、χ2检验、T检验等对血浊证人群临床资料进行了一般性描述和分析;通过logistic回归模型分析,明确了血浊证的主要影响因素、主要症状和实验室诊断指标,并且对血浊证主要症状的logistic回归模型进行了验证,结果证明具有较好的预测性。结论:急性脑梗塞患病人群入院前血浊证的主要症状为乏力、失眠、行动不稳、言语不利、头晕、肢体活动不灵;有意义的实验室诊断指标为纤维蛋白原、胆固醇、甘油三脂、低密度的脂蛋白;主要的影响因素是精神因素、环境污染、不良饮食习惯、吸烟、高血压家族史、糖尿病史、年龄。更多还原

【Abstract】 Objective: To explore the main symptoms,experimental diagnosis standard and influential factors about Bloody Dirtiness syndrome before going hospital for patients suffering from acute cerebral infarction. Providing sciencial evidence for further diagnosis, early effective prevention and treatment of Bloody Dirtiness syndrome. Methods: Through the methods of clinical epidemiology study,many aspects of Bloody Dirtiness syndrom were deeply investigated, such as the influential factors,main symptoms,the experi- mental diagnosis standard and developing rule by some means as follows: review of litera- ture, consultation with experts, formulation of questionnaire,excavation of numerical data and analysis of medical principle. Making questionnaire dually perfect through small sample survey,reliability and validity evaluation. Results: The investigative questionnaire about epidemiology study of Bloody Dirtiness syndrome before going hospital for patients suffering from acute cerebral infarction was formulated. And by large sample survey,the questionnaire was found to have good reliability and validity efficiency. The general clinical meterials of investigated objective were described and analysized by means of statistics such as frequency,means,χ2 test and T test. The main influential factors,sym- ptoms and the experimental diagnosis standard of Bloody Dirtiness syndrom were revealed by analysis of stepwise regression of Logistic. Furthermore,the predictability of syndrome model was good. Conclusion: The main symptoms about Bloody Dirtiness syndrome before going hospital for patients suffering from acute cerebral infarction are listlessness,insomnia,unstability in activity,out of fluency in speaking,dizziness and inflexibility in activity of limb. The significant experimental diagnosis standard are Fibrinogen, Cholesterol, Triglyceride and LDL-C. The main influential factors are spirit, environ- mental pollution,bad habit of appetite,appetite for smoke,family history of hypertension, diabetes history and age.更多还原