【作者】 康辉；

【导师】 贾连顺； 袁文； 欧阳跃平； 陈雄生； 史建刚； 宋滇文；

【作者基本信息】 第二军医大学 ， 外科学， 2008， 博士

【摘要】 目的探讨椎间盘纤维环交感神经分布与青少年特发性脊柱侧凸发病的相关性。方法先建立山羊脊柱侧凸模型,将椎间盘纤维环分为左前、左后、右前、右后四个区,然后通过NF200常规荧光组化和乙醛酸染色来研究正常山羊、侧凸山羊、正常人和青少年特发性脊柱侧凸患者椎间盘不同部位纤维环的交感神经分布特点。结果成功构建山羊脊柱侧凸模型,研究发现正常山羊椎间盘纤维环四个区的交感神经分布无显著差异;侧凸山羊顶椎区椎间盘凸凹侧纤维环交感神经分布无显著差异;正常人椎间盘纤维环四个区的交感神经分布无显著差异;青少年特发性脊柱侧凸患者顶椎区椎间盘凸凹侧纤维环交感神经分布有显著差异,凸侧明显多于凹侧。结论椎间盘纤维环左右两侧的交感神经分布差异可能是青少年特发性脊柱侧凸的发病原因之一。更多还原

【Abstract】 Objective To study the associativity between the distribution of sympathetic nerve in annulus fibrosus disci intervertebralis and the onset of adolescent idiopathic scoliosis.Methods First,create goat scoliosis model.Each intervertebral disc is divided into four sections-the front left disc,the rear left disc,the front right disc and the rear right disc.Then study sympathetic nerves distribution characteristic of various section in annulus fibrosus disci intervertebralis of goat through NF200 conventional fluorescence dyeing and glyoxalic acid dyeing. meanwhile,scoliosis goats,normal peoples,and AISs,using the same method.Results Succeed in establishing goat scoliosis model.Result shows that there is no significant difference in distribution of any two(out of four) sections’ sympathetic nerve in normal goats annulus fibrosus disci intervertebralis,there is no significant difference between the sympathetic fibers distribution of convex side and concave side in annulus fibrosus disci intervertebralis of scoliosis goat apical vertebral,there is no significant difference in distribution of any two(out of four) sections’ sympathetic fiber in normal peoples annulus fibrosus disci intervertebralis,and there is significant difference between the sympathetic fiber distribution of convex side and concave side in annulus fibrosus disci intervertebralis of AIS apical vertebral-the sympathetic nerve supply of convex side to gain advantage concave side.Conclusions Left and right difference in the distribution of sympathetic nerve in annulus fibrosus disci intervertebralis may be one of etiopathogenisis to the onset of adolescent idiopathic scoliosis.更多还原