【作者】 刘军楼；

【导师】 许国铭； 李兆申； 邹多武；

【作者基本信息】 第二军医大学 ， 内科学， 2007， 博士

【摘要】 目的:验证放射性胰胆管塑料支架设计是否可行;评价放射性支架的可行性及安全性。方法:设计出放射性胰胆管塑料支架,动物实验进行可行性观察;以猪为研究对象胰胆管植入放射性支架,根据TPS计算的参考点照射剂量分为3组,A组50 Gy,B组100 Gy,C组150 Gy,术后随访观察。结果:支架通畅,支架上粒子没有发生脱落;部分支架移位,周围相邻脏器未发现明显异常。血液检查未发现明显严重异常。放射性胰管支架组,胰管壁正常形态结构消失;放射性胆管支架组未出现胆管穿孔,黏膜层上皮坏死,50Gy组黏膜腺体轻度增生,100 Gy组黏膜腺体无明显增生,150 Gy组黏膜腺体明显减少。结论:放射性胰胆管支架设计是可行的;支架是安全可行的;可以通过TPS设计出个体化的放射支架。更多还原

【Abstract】 Objective : To test the feasibility of the radioactive plastic stents;To evaluate the feasibility and safety of the radioactive stents. Methods:Radioactive plastic stents were designed and its feasibility was tested in animal;Healthy pigs were used in this study ,they were were divided into three groups on the basis of radiation dose and implanted radioactive stents in the pancreatic or bile duct. The radiation dose of the reference point calculated by TPS was 50 Gy in Group A, 100 Gy in Group B,and 150 Gy in Group C. The pigs were followed up after implantation.Results: None of the stents were obstructed and all the seeds remained in the original position of the stents.The migration of some stents was found .There were no obvious dysfunction in the adjacent organs.There were no serious abnormalities noted on blood tests.In the groups of radioactive pancreatic duct stents, the normal morphological structure of the pancreatic duct wall disappeared;In the groups of radioactive bile duct stents,perforation of the common bile duct was not observed and necrosis of mucosal layer existed.In 50Gy Group mild hyperplasia of mucosal glands was seen. In 100Gy Group almost no hyperplasia of the mucosal glands could be found. In 150Gy Group mucosal glands obviously decreased .Conclusions:The design of radioactive plastic stents is feasible;The radioactive stents are safe and feasible;It is feasible to design a special radioactive stent through TPS.更多还原