【作者】 张莉；

【导师】 哈木拉提·吾甫尔；

【作者基本信息】 新疆医科大学 ， 心血管， 2006， 博士

【摘要】 随着细胞生物学、分子生物学以及基因组学等基础研究的发展，癌症的发病机制和临床治疗方面取得了长足的进步，某些恶性肿瘤，如早期宫颈癌、乳腺癌等已可达到根治。但是多数恶性肿瘤的治疗迄今未根本解决。即使治愈率很高的恶性肿瘤在治疗后部分病人在若干年后还会有远处转移。科学家们从基因组学等更微观的层次研究癌症，无疑对揭示其发病机制和治愈癌症有着十分重要的作用。但是毕竟生命活动和疾病的发生、发展不能仅仅用单个细胞、单个基因发生改变解释，应该从机体的稳态和整体出发。神经-内分泌-免疫网络(Neuro-endocrine-immune，NEI)概念的精髓是机体通过神经、内分泌和免疫三大相互独立又密不可分的系统维持着机体的稳态和平衡。它们之间相互作用是通过神经递质、激素和细胞因子介导。这个网络中的任何一个环节出现严重失衡，都会明显影响其他系统的功能，导致相关疾病的发生。早在1984年Rosch提出，机体的激素水平和免疫状况是影响肿瘤生长的两种最主要的内在因素。但是，总体上整个机体对肿瘤发生、发展的重要性没有得到足够的重视，更没有成为肿瘤治疗的主流。癌症既然是细胞异常生长为特征的疾病，机体对细胞生长的调节系统应是多方位、多层次的。 维吾尔医学历来非常重视人体本身的统一性、完整性及其与自然界的相互联系，认为人体是一个有机整体，构成人体的各个脏器、组织或器官，在结构上是不可分割的。维吾尔医关于体液论有如下的阐更多还原

【Abstract】 With the development of the cytobiology and molecular biology, pathogenesis and therapy of cancer have been improved, some caners like early stage cervical cancer and breast cancer can be cured. However, the fundamental therapy in most of them is still undone. Some cancer inevitably metastasizes after radical cure. Genomics research from microcosmic plays an important role in revealing the pathogenesis and therapy of cancer. But vital movement and diseases couldn’t be explained by sing cell, or gene, the homeostasis of organism should be emphasized. The essence of the neuro-endocrine-immune network is to keep the homeostasis and balance of organism by the three interdependent systems-nervous, endocrine and immune system. The interaction between them is mediated by the nervous transmitters, hormones and cytokines. Any part disbalance of the network must obviously impair other’s function and lead to disorder. In 1984, Rosch pointed out that environmental carcinogenic agent was responsible for the cancer via physical and chemical agents; meanwhile the level of hormones and cytokines were the most important internal agents for regulating the development of cancer. The disorder of the neuro-endocrine-immune was involved in many malignant carcinomas carcinogens and development. Now that cancer is characterized by the cellular abnormal growth, the更多还原