【作者】 刘春玲；

【导师】 唐蜀华；

【作者基本信息】 南京中医药大学 ， 中医内科心血管， 2006， 博士

【摘要】 背景 动脉粥样硬化(atherosclerosis，AS)是心脑血管疾病的主要病理基础。它是发达国家人口死亡的主要原因，在发展中国家发病率和死亡率也越来越高，因此动脉粥样硬化的发病机制和抗动脉粥样硬化药物越来越成为研究的热点。其发病机理的研究以往主要围绕三种学说：脂质浸润学说、血栓形成学说和损伤反应学说。随着研究的逐步深入，1999年Ross R教授在损伤反应学说的基础上，明确提出“AS是一种炎症性疾病”。其过程涉及到一些化学因子、细胞因子及免疫因子，这些因子将AS灶内各种细胞间通过自分泌与旁分泌，相互联系，相互影响，促进病变的发展。国内外多数研究认为，动脉粥样硬化发展是一个多因素的复杂病理过程，其中心环节是低密度脂蛋白胆固醇(LDL-C)沉积在血管壁，随之氧化修饰，炎症细胞聚集、侵入和激活，导致动脉粥样硬化的产生。其中炎症反应贯穿了AS发生、发展的整个过程，与斑块的形成及稳定密切相关。与防治血栓和再血管化相比，稳定斑块更具实际意义。芦黄颗粒是唐蜀华教授在多年临床实践的基础上总结而成的经验方，具有良好疗效。以补益肝肾、活血清热解毒并治为原则，由黄精、首乌、姜黄、红花、虎杖、漏芦诸药组成。现代药理研究表明，上述药物可从不同环节发挥调脂、抗AS作用。我们通过建立动脉粥样硬化动物模型，观察养阴活血、清热解毒方芦黄颗粒抗动脉粥样硬化的作用，旨在开发中药干预动脉粥样硬化的新视角。 目的 通过建立实验性动脉粥样硬化的动物模型，观察芦黄颗粒抗动脉粥样硬化的作用，并对其机制加以探讨。 (1)观察芦黄颗粒对AS兔血脂及血清脂质过氧化的影响，了解芦黄颗粒的调脂作用。更多还原

【Abstract】 BackgroundAtherosclerosis is the pathological basis of cardiovascular and cerebrovascular diseases. It is the main cause of death in developed countries, as well as in developing countries, of which the morbitidy and mortality are getting higher and higher. So studies on the mechanism and the treatment of atherosclerosis have been the focus of intense research. There are three throries involved in the research on atherosclerosis, which are lipid infiltration theory, thrombogenic theory and reponse-to-injury hypothesis. With the development of the mechanism of atherosclerosis, Professor Ross R suggested "atherosclerosis: an inflammatory disease" based on reponse-to-injury hypothesis in 1999. Some chemical factors, cytokines and immunologic facrors are related to contact and interact all kinds of cells through autocrinism and paracrine secretion in atherosclerotic lesions, as a result of promoting the development of atherosclerosis. Numerous studies indicate that atherosclerosis is a multifactorial, complex pathological process. The main step is the deposition of low density lipoprotein-cholesterol, then oxidative modification, inflammation cell congregating, invading and activating, therefore atherosclerosis developed. The inflammatory response runs through the total process of atherosclerosis, which is tightly concered with the formation and stability of plaque. It is more important to stabilize plaque than to control thrombus and revascularization. Luhuang Granule is created by Professor Tang Shuhua, which is based on his clinical practice with satisfactory results. Luhuang Granule, consisting of Rhizoma Polygontal, Radix Plygoni Multiflori, Rhizoma Curcumae Longae, Flos Carthami, Rhizma Polgoni Cuspidati and Uniflower更多还原