【作者】 张晓雷；

【导师】 谢宁；

【作者基本信息】 黑龙江中医药大学 ， 中医基础理论， 2006， 博士

【摘要】 目的:观察加减地黄饮子治疗AD的临床疗效。 方法:采用随机、对照方法将56例观察病例随机分为治疗组加减地黄饮子30例,对照组脑复新片26例。对临床症状、神经心理学、血脂参数、血液流变学参数、自由基参数、一氧化氮参数及脑血流速度等指标进行临床观察,并将观察结果进行分析和总结。 结果:加减地黄饮子能显著改善AD患者痴呆主要症状和中医临床症状;该方通过改善MMSE、HDS、FAQ积分,显示出对神经心理学方面具有一定的作用;该方能够改善血脂,降低血清TC、LDL-C,升高HDL;该方能够降低血液粘度,对除血沉外的血液流变学各项指标均有改善作用;该方能够增强血浆SOD活性,降低血浆过氧化脂质LPO、MDA含量,调节自由基失衡,减轻自由基对脑组织的损害;该方还能够降低AD患者血浆中NO含量和NOS活性,从而减少对神经元的损伤;此外,该方还能够加快脑血流速度,增加脑血流量,改善脑循环。 结论:加减地黄饮子通过改善AD患者临床症状、降低血脂、改善血液粘度、调节自由基失衡、降低血浆中NO含量和NOS活性、加快脑血流速度,对AD有较为确切的临床疗效。更多还原

【Abstract】 Aim: observing the clinical effect on Althemer’ s disease treatment by adding or substracting the recipe of Dihuang Yinzi.Methed: we divided the 56 patients of AD into two parts by randoming and contrasting.One is treated by the recipe of Dihuang Yinzi.The other is treated by Nao fuxin.We observe these patients in symptoms,nerve psychology,blood lipid level,hemodynamic changes,free base,monoxide nitrogen and blood speed in the brain, random the results in the set and between the two sets.Result: we reach Results as follows:the recipe can improve patients symptoms and partal targets on blood lipid level and hemodynamic changes;the recipe can adjust the balance of the free-base and ligen the harm on the brain;the recipe can reduce the content of NO and the active of NOS,reduce the harm on neuron,quicken the blood speed of the brain,improve the brain cycle.Conclusions: through improving symptoms,partal targets on blood lipid level and hemodynamic changes,adjusting the balance of the free-base and ligening the harm on the brain,reducing the content of NO and the active of NOS,quickening the blood speed of the brain,we reach a conclusions as follows: the recipe of Dihuang Yinzi have exact effect on AD.更多还原