【作者】 曹殿波；

【导师】 杨海山；

【作者基本信息】 吉林大学 ， 放射医学， 2006， 博士

【摘要】 血管栓塞治疗解决了临床许多棘手的难题,选择恰当的栓塞材料对可靠的疗效十分重要。目前栓塞材料大部分依靠进口,昂贵的价格限制了临床应用,迫切需要国产化研究。研究合作实验室掌握了PVA制备的关键技术与环节,并能根据需要制备出各种大小的PVA颗粒。对材料的亲水性、吸水倍数、吸水后的膨胀变形率和密度等重要物理性能均进行了测试,得到了科学的数据。在自制PVA颗粒与进口PVA颗粒电镜比较时,两者形态结构相似。体外毒性实验研究证实了自制PVA颗粒的安全性。以进口PVA颗粒作为对照组,采用介入导管栓塞技术行兔右肾动脉栓塞来考察栓塞效果。在影像学上应用CTA和DSA进行评价,在组织病理学上观察栓塞材料对栓塞动脉及肾实质的影响。研究结果表明:自制PVA颗粒具有较好的组织相容性,与进口PVA颗粒有相似的栓塞效果。所以自制PVA颗粒可作为血管栓塞剂,但在临床应用上还需进一步深入研究。本实验研究首次应用CTA检查评价栓塞效果,证实了其与DSA具有相似的效果,为栓塞材料的研发找到了合适的、准确的评价方法;与此同时,也完善了导管栓塞技术,明确颈动脉插管是对股动脉插管失败后的一个有效的弥补方法。更多还原

【Abstract】 ObjectiveTo study the preparation methods and physical-chemical properties of PVA material; To assess the safety and embolic effect of self-made PVA particles as arterial embolic agent. To compare the efficacies of different imaging methods in evaluating embolic effect and summarize the experimental experiences of transcatheter renal arterial embolization in rabbits.Materials and Methods1 Laboratory preparation of self-made PVA materialWe developed a method to prepare PVA absorbent material by mixing Polyvinylalcohol together with formaldehyde with rapid agitation. The surface density, multiplication after absorbing water, volume increase rate after absorbing water, climbing height after absorbing water and its morphological structure were measured.2. Animal experiment of prepared PVA particles2.1 Sterile test, fever-induced test, blood compatiblity, histocompatiblity test and toxic test were done for prepared PVA particles.2.2 Embolization procedure and observation indicators28 New Zealand adult rabbits were classified as Group A and Group B. Group A (n=12) received right renal artery embolization with commercially available PVA particles, while Group B (n= 16) with PVA particles prepared in our laboratory. Su-mian-xin II was injected through ear edge vein for anesthesia in all animals. After successful anesthesia, an angiography catheter was inserted更多还原